全部文献期刊会议图书|学者科研项目
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作者:Paul H. Goldspink , Amit Sharma ...
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (1), pp.1-11
摘要:Abstract Cardiac fibrosis is an underlying cause of diastolic dysfunction, contributing to heart failure. Substance P (SP) activation of the neurokinin-1 receptor (NK-1R) contributes to cardiac fibrosis in hypertension. However, based on in vitro experiments, this does not appear...
作者:... Perla Ayala , Tejal A. Desai , Paul H. Goldspink
来源:[J].Biomaterials(IF 7.604), 2015, Vol.46, pp.26-34
摘要:Abstract(#br)The Insulin like growth factor-I isoform mechano-growth factor (MGF), is expressed in the heart following myocardial infarction and encodes a unique E-domain region. To examine E-domain function, we delivered a synthetic peptide corresponding to the unique E-dom...
作者:Paul H. Goldspink , Aldrin V. Gomes ...
来源:[J].Archives of Biochemistry and Biophysics(IF 3.37), 2014, Vol.552-553, pp.50-59
摘要:Abstract(#br)Chronic increases in myofilament Ca 2+ -sensitivity in the heart are known to alter gene expression potentially modifying Ca 2+ -homeostasis and inducing arrhythmias. We tested age-dependent effects of a chronic increase in myofilament Ca 2+ -sensitivity on indu...
作者:Paul H. Goldspink , R. John Solaro
来源:[J].Journal of Molecular and Cellular Cardiology(IF 5.148), 2014, Vol.72, pp.281-291
摘要:Abstract(#br)Up-regulation and activation of PYK2, a member of the FAK family of protein tyrosine kinases, is involved in the pathogenesis of left ventricular (LV) remodeling and heart failure (HF). PYK2 activation can be prevented by CRNK, the C-terminal domain of PYK2. We ...
作者:Paul H. Goldspink , Evangelia G. Kranias ...
来源:[J].Journal of Molecular and Cellular Cardiology(IF 5.148), 2011, Vol.51 (5), pp.812-820
摘要:Abstract(#br)We have recently shown that a temporary increase in sarcoplasmic reticulum (SR) cycling via adenovirus-mediated overexpression of sarcoplasmic reticulum ATPase (SERCA2) transiently improves relaxation and delays hypertrophic remodeling in a familial hypertrophic...
作者:... Pieter de Tombe , Paul H. Goldspink , Brenda Russell
来源:[J].Journal of Molecular and Cellular Cardiology(IF 5.148), 2008, Vol.45 (6), pp.853-856
摘要:Abstract(#br)The design of a novel transduction complex has permitted the introduction of protein–quantum dot conjugates into the cytoplasm of living cells. Appropriate subcellular localization of quantum dot-conjugated cardiac troponin C to the myofibrils and a nuclear pept...
作者:John M. Collins , Paul H. Goldspink , Brenda Russell
来源:[J].Journal of Molecular and Cellular Cardiology(IF 5.148), 2010, Vol.49 (6), pp.1042-1045
摘要:Abstract(#br)Stem cell function is thought to be tightly regulated by growth factor concentration in the confines of the microenvironmental niche. Therefore, the response of human mesenchymal stem cells (hMSCs) was studied in culture with mechano-growth factor (MGF), an isof...
作者:Paul H. Goldspink , R. John Solaro ...
来源:[J].Journal of Molecular and Cellular Cardiology(IF 5.148), 2010, Vol.49 (6), pp.993-1002
摘要:Abstract(#br)Familial hypertrophic cardiomyopathy (FHC) is an autosomal dominant genetic disorder linked to numerous mutations in the sarcomeric proteins. The clinical presentation of FHC is highly variable, but it is a major cause of sudden cardiac death in young adults wit...
作者:... R. John Solaro , Peter M. Buttrick , Paul H. Goldspink
来源:[J].Journal of Molecular and Cellular Cardiology(IF 5.148), 2005, Vol.40 (4), pp.465-473
摘要:Abstract(#br)We have previously reported a transgenic mouse that over-expresses constitutively active PKCε in the myocardium and exhibits a steady progression to heart failure. Associated with the decline in function was an increased phosphorylation of sarcomeric proteins in...

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