全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
中外文文献  中文文献  外文文献
作者:... Timo J. Nevalainen , Paul F. Alewood , Bryan G. Fry
来源:[J].Toxins(IF 2.129), 2015, Vol.7 (6), pp.2251-2271DOAJ
摘要:Cnidarians are the oldest extant lineage of venomous animals. Despite their simple anatomy, they are capable of subduing or repelling prey and predator species that are far more complex and recently evolved. Utilizing specialized penetrating nematocysts, cnidarians inject th...
作者:Paul F. Alewood , Richard J. Lewis
来源:[J].Toxins(IF 2.129), 2016, Vol.8 (3)DOAJ
摘要:Loss-of-function mutations of NaV1.7 lead to congenital insensitivity to pain, a rare condition resulting in individuals who are otherwise normal except for the inability to sense pain, making pharmacological inhibition of NaV1.7 a promising therapeutic strategy for the trea...
作者:Paul F. Alewood , Mehdi Mobli ...
来源:[J].Marine Drugs(IF 3.978), 2012, Vol.10 (7), pp.1511-1527DOAJ
摘要:APETx2 is a peptide isolated from the sea anemone Anthopleura elegantissima . It is the most potent and selective inhibitor of acid-sensing ion channel 3 (ASIC3) and it is currently in preclinical studies as a novel analgesic for the treatment of chronic inflammatory pain. As a p...
作者:... Volker Herzig , Glenn F. King , Paul F. Alewood
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2013, Vol.70 (19), pp.3665-3693Springer
摘要:Abstract(#br)Pest insect species are a burden to humans as they destroy crops and serve as vectors for a wide range of diseases including malaria and dengue. Chemical insecticides are currently the dominant approach for combating these pests. However, the de-registration of ...
作者:... Natalie Steen , David J. Craik , Paul F. Alewood
来源:[J].Toxicon(IF 2.924), 2014, Vol.90, pp.308-317Elsevier
摘要:Abstract(#br)In the past 100 years minimal venom research has focused on ticks despite several species possessing a highly paralytic and lethal venom cocktail of proteinaceous molecules. The saliva of the Australian paralysis tick, Ixodes holocyclus , has been responsible for 20 ...
作者:... Nathan Dunstan , Bryan Fry , Paul F. Alewood
来源:[J].Journal of Proteomics(IF 4.088), 2016, Vol.133, pp.20-32Elsevier
摘要:Abstract(#br)Australian elapid venom remains an under-investigated resource of novel bioactive peptides. In this study, the venom gland transcriptomes and proteomes of the Australian western brown snakes, Pseudonaja aspidorhyncha and Pseudonaja nuchalis , were compared to Pseudon...
作者:... Richard J. Lewis , David J. Adams , Paul F. Alewood
来源:[J].Biochemical Pharmacology(IF 4.576), 2014, Vol.91 (4), pp.534-542Elsevier
摘要:Abstract(#br)Neuronal nicotinic acetylcholine receptors (nAChRs) are a diverse class of ligand-gated ion channels involved in neurological conditions such as neuropathic pain and Alzheimer's disease. α-Conotoxin [A10L]PnIA is a potent and selective antagonist of the mammalia...
作者:Paul F. Alewood , Laurie L. Parker ...
来源:[J].Current Biology(IF 9.494), 2014, Vol.24 (5), pp.473-483Elsevier
摘要:Summary(#br)Background(#br)The venoms of predators have been an excellent source of diverse highly specific peptides targeting ion channels. Here we describe the first known peptide antagonist of the nociceptor ion channel transient receptor potential ankyrin 1 (TRPA1).(#br)...
作者:... David J. Adams , Paul F. Alewood , Lachlan D. Rash
来源:[J].Biochemical Pharmacology(IF 4.576), 2014, Vol.89 (2), pp.276-286Elsevier
摘要:Abstract(#br)Spider venoms are replete with peptidic ion channel modulators, often with novel subtype selectivity, making them a rich source of pharmacological tools and drug leads. In a search for subtype-selective blockers of voltage-gated calcium (Ca V ) channels, we isol...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×