全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Thomas G. Beach , Paul D. Coleman , Matthew J. Huentelman
来源:[J].Brain Research(IF 2.879), 2019, Vol.1719, pp.217-224Elsevier
摘要:Abstract(#br)We explored RNA expression changes in the middle temporal gyrus (MTG) of Alzheimer’s Disease patients (AD) by RNA sequencing the whole transcriptome of 8 AD and 8 Non-Demented (ND) controls. We used three additional expression datasets from related brain regions...
作者:Paul D. Coleman
来源:[J].Neurobiology of Aging(IF 6.166), 2014, Vol.35 (11), pp.2427-2427Elsevier
作者:... Andrew Grover , Salvatore Oddo , Paul D. Coleman
来源:[J].Neurobiology of Aging(IF 6.166), 2015, Vol.36 (12), pp.3121-3129Elsevier
摘要:Abstract(#br)We have previously reported in Alzheimer's disease (AD) the mislocalization of epigenetic molecules between the cell nucleus and the cytoplasm. We have extended our finding to include the aberrant localization of histone 3 trimethylation on lysine 4 (H3k4me3), an epi...
作者:... Carl Cotman , Sidney M. Hecht , Paul D. Coleman
来源:[J].Alzheimer's & Dementia: The Journal of the Alzheimer's Association(IF 14.483), 2016Elsevier
摘要:Abstract(#br)Introduction(#br)We have comprehensively described the expression profiles of mitochondrial DNA and nuclear DNA genes that encode subunits of the respiratory oxidative phosphorylation (OXPHOS) complexes (I–V) in the hippocampus from young controls, age matched, ...
作者:Paul D. Coleman , Bart P.F. Rutten
来源:[J].Neurobiology of Aging(IF 6.166), 2013, Vol.34 (9), pp.2091-2099Elsevier
摘要:Abstract(#br)Epigenetic dysregulation of gene expression is thought to be critically involved in the pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation and DNA hydroxymethylation are 2 important epigenetic mechanisms that regulate gene ...

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