全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Jeffrey J. Lochhead , Patrick T. Ronaldson , Thomas P. Davis
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (4), pp.910-920Springer
摘要:A functional blood-brain barrier (BBB) is necessary to maintain central nervous system (CNS) homeostasis. Many diseases affecting the CNS, however, alter the functional integrity of the BBB. It has been shown that various diseases and physiological stressors can impact the B...
作者:Wazir Abdullahi , Thomas P. Davis , Patrick T. Ronaldson
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (4), pp.931-939Springer
摘要:Drug delivery to the central nervous system (CNS) is greatly limited by the blood-brain barrier (BBB). Physical and biochemical properties of the BBB have rendered treatment of CNS diseases, including those with a hypoxia/reoxygenation (H/R) component, extremely difficult. T...
作者:Kathryn Ibbotson , Joshua Yell , Patrick T. Ronaldson
来源:[J].Fluids and Barriers of the CNS, 2017, Vol.14 (1)Springer
摘要:Strategies to maintain BBB integrity in diseases with a hypoxia/reoxygenation (H/R) component involve preventing glutathione (GSH) loss from endothelial cells. GSH efflux transporters include multidrug resistance proteins (Mrps). Therefore, characterization of Mrp regulation at t...
作者:Patrick T. Ronaldson , Thomas P. Davis
来源:[J].Brain Research(IF 2.879), 2015, Vol.1623, pp.39-52Elsevier
摘要:Abstract(#br)The blood–brain barrier (BBB) is a physical and biochemical barrier that precisely regulates the ability of endogenous and exogenous substances to accumulate within brain tissue. It possesses structural and biochemical features (i.e., tight junction and adherens...
作者:Patrick T. Ronaldson , Reina Bendayan
来源:[J].European Journal of Pharmaceutics and Biopharmaceutics(IF 3.826), 2005, Vol.62 (3), pp.321-331Elsevier
摘要:Abstract(#br)To better understand and design microsphere systems for the locoregional delivery of anticancer drug combinations to solid tumors, (1) the cytotoxicity of microsphere-delivered mitomycin C (MMC) was evaluated and (2) various schedules of MMC and doxorubicin (Dox) wer...
作者:Patrick T. Ronaldson , Gloria Lee ...
来源:[J].Pharmaceutical Research(IF 4.742), 2004, Vol.21 (5), pp.811-818Springer
摘要:Abstract(#br) Purpose. Membrane-bound efflux transporters, such as P-glycoprotein (P-gp), may limit the brain entry and distribution of HIV-1 protease inhibitors and be in part responsible for HIV-1-associated dementia treatment failure. The purpose of this study was to character...
作者:... Mei‐Li Laracuente , Patrick T. Ronaldson , Thomas P. Davis
来源:[J].Journal of Neurochemistry(IF 3.973), 2012, Vol.122 (5), pp.962-975Wiley
摘要:J. Neurochem. (2012) 122 , 962–975.(#br)Abstract(#br)P‐glycoprotein (ABCB1/MDR1, EC 3.6.3.44), the major efflux transporter at the blood–brain barrier (BBB), is a formidable obstacle to CNS pharmacotherapy. Understanding the mechanism(s) for increased P‐glycoprotein act...
作者:... Kristin M. DeMarco , Patrick T. Ronaldson , Thomas P. Davis
来源:[J].PLOS ONE(IF 3.73), 2014, Vol.9 (2)PLOS
摘要:Our laboratory has previously demonstrated that peripheral inflammatory pain (PIP), induced by subcutaneous plantar injection of λ-carrageenan, results in increased expression and activity of the ATP-dependent efflux transporter P-glycoprotein (P-gp) that is endogenously exp...

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