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作者:Patrick Mougenot , Claudie Namane ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2016, Vol.26 (1), pp.25-32Elsevier
摘要:Abstract(#br)Chemical modulation of a formerly disclosed DGAT-1 inhibitor resulted in the identification of a compound with a suitable profile for preclinical development. Optimisation of solubility is discussed and a PK/PD study is presented.
作者:Patrick Mougenot , Claudie Namane ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2012, Vol.22 (7), pp.2497-2502Elsevier
摘要:Abstract(#br)A novel class of DGAT1 inhibitors containing a thiadiazole core has been discovered. Chemical optimization lead to inhibitors of human DGAT1 with an appropriate ADME profile and that show in vivo activity in target tissues.
作者:Patrick Mougenot , Michel Koch ...
来源:[J].Journal of Colloid And Interface Science(IF 3.172), 1996, Vol.177 (1), pp.162-170Elsevier
摘要:Abstract(#br)Surface functionalization of polyethylene terephthalate film and track-etched microporous membranes was performed using organic synthesis at the solid–liquid interface. The hydroxyl chain ends, naturally occurring in the membranes or created by basic hydrolysis ...
作者:Patrick Mougenot , Olivier Crespin ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2013, Vol.23 (8), pp.2414-2421Elsevier
摘要:Abstract(#br)Starting from 11β-HSD1 inhibitors that were active ex vivo but with Cyp 3A4 liability, we obtained a new series of adamantane ureas displaying potent inhibition of both human and rodent 11β-HSD1 enzymes, devoid of Cyp 3A4 interactions, and rationally designed to...
作者:Patrick Mougenot , Olivier Crespin ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2011, Vol.21 (8), pp.2244-2251Elsevier
摘要:Abstract(#br)A High Throughput Screening campaign allowed the identification of a novel class of ureas as 11β-HSD1 inhibitors. Rational chemical optimization provided potent and selective inhibitors of both human and murine 11β-HSD1 with an appropriate ADME profile and ex vi...
作者:Patrick Mougenot , Yves‐Jacques Schneider
来源:[J].Polymers for Advanced Technologies(IF 1.635), 1996, Vol.7 (7), pp.589-598Wiley
摘要:Abstract(#br)Poly(ethylene terephthalate) (PET) films and track‐etched microporous membranes naturally display, on their surfaces, reactive chain‐ends, i.e. carboxyl and hydroxyl functions. These were assayed by suitable activation (reaction with carbodiimide and tosyl chlor...
作者:Patrick Mougenot , Alain Braun ...
来源:[J].Synthesis(IF 2.5), 2000, Vol.2000 (1), pp.127-134Thieme
摘要:Asymmetric dihydroxylation (AD) with an AD-mix reagent was conducted on a series of terminal olefins possessing an extended heteroaromatic group. Good yields and high enantioselectivities were observed in most instances. However, the steric hindrance resulting from neighboring su...

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