全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Patrick Imesch , Konstantin J Dedes ...
来源:[J].BMC Cancer(IF 3.333), 2011, Vol.11 (1)Springer
摘要:Abstract(#br) Background(#br)Epigenetic regulation is an important mechanism leading to cancer initiation and promotion. Histone acetylation by histone deacetylases (HDACs) represents an important part of it. The development of HDAC inhibitors has identified the utility of HDACs ...
作者:... Zsuzsanna Varga , Daniel Fink , Patrick Imesch
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (1)DOAJ
摘要:INTRODUCTION: The G protein-coupled estrogen receptor (GPER) is a novel estrogen receptor that mediates proliferative effects induced by estrogen but also by tamoxifen. The aim of our study was to analyze the frequency of GPER in a large collective of primary invasive breast carc...
作者:Patrick Imesch , Kristian Ikenberg ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (6)DOAJ
摘要:To evaluate the frequency of MRE11/RAD50/NBS1 (MRN)-complex loss of protein expression in endometrial cancers (EC) and to determine whether loss of MRE11 renders the cancer cells sensitive to Poly(ADP-ribose) polymerase (PARP)-inhibitory treatment.MRN expression was examined in 5...
作者:... Daniel Fink , Andreas Boss , Patrick Imesch
来源:[J].Archives of Gynecology and Obstetrics(IF 1.33), 2019, Vol.300 (1), pp.109-116Springer
摘要:Abstract(#br) Purpose(#br)Comparison of preoperative magnetic resonance imaging (MRI) with intraoperative findings in patients with deep infiltrating endometriosis (DIE) by means of the ENZIAN score.(#br) Methods(#br)This retrospective two-center study includes 63 patients with d...
作者:Patrick Imesch , Daniel Fink
来源:[J].Targeted Oncology(IF 2.764), 2015, Vol.10 (2), pp.297-301Springer
摘要:Abstract(#br)Metastatic breast cancer is considered an incurable disease. Targeted treatments against the human epidermal growth factor receptor 2 (HER2), however, significantly improve survival in patients with metastatic HER2-positive breast cancer. Some patients may respond wi...
作者:Patrick Imesch , Eleftherios P. Samartzis ...
来源:[J].Fertility and Sterility(IF 4.174), 2013, Vol.100 (3), pp.770-776Elsevier
摘要:Objective(#br)To investigate whether histone deacetylase inhibitors reduce the expression of the G-protein-coupled estrogen receptor (GPER) and whether the functional inhibition of GPER by the antagonist G-15 decreases the proliferation of endometriotic cells.(#br)Design(#br...
作者:Patrick Imesch , Anja Twiehaus ...
来源:[J].Gynecological Endocrinology(IF 1.303), 2016, Vol.32 (7), pp.529-533Taylor & Francis
摘要:Abstract(#br)Endometriosis, a painful disorder associated with infertility, is estimated to occur in approximately 7–10% of reproductive age women. Although endometriosis is considered as an estrogen-dependent disease, the role of estrogen metabolites via receptor-independen...
作者:Patrick Imesch , Daniel Fink , André Fedier
来源:[J].Fertility and Sterility(IF 4.174), 2010, Vol.94 (7), pp.2838-2842Elsevier
摘要:Romidepsin inhibited HDAC activity, produced acetylation of the histone proteins, up-regulated p21, and down-regulated cyclins B1 and D1, resulting in proliferation inhibition and apoptosis activation in 11z immortalized epithelial endometriotic cells. Our findings provide eviden...
作者:Patrick Imesch , Eleftherios P. Samartzis ...
来源:[J].Fertility and Sterility(IF 4.174), 2010, Vol.95 (5), pp.1579-1583Elsevier
摘要:Objective(#br)To investigate whether the histone deacetylase (HDAC) inhibitor romidepsin down-regulates VEGF (vascular endothelial growth factor) gene expression and abrogates VEGF protein secretion in human epithelial endometriotic cells.(#br)Design(#br)In vitro study with ...

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