全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Palani Kirubakaran , Ignacio Hernando Pato ...
来源:[J].International Journal of Biological Macromolecules(IF 2.596), 2017Elsevier
摘要:Abstract(#br)Human DHRS7 (SDR34C1) is one of insufficiently described enzymes of the short-chain dehydrogenase/reductase superfamily. The members of this superfamily often play an important pato/physiological role in the human body, participating in the metabolism of diverse...
作者:Palani Kirubakaran , Martin Jaček ...
来源:[J].Toxicology and Applied Pharmacology(IF 3.975), 2018, Vol.347, pp.79-91Elsevier
摘要:Abstract(#br)We tested the role of substituents at the C3′ and C3′N positions of the taxane molecule to identify taxane derivatives capable of overcoming acquired resistance to paclitaxel. Paclitaxel-resistant sublines SK-BR-3/PacR and MCF-7/PacR as well as the original pacl...
作者:Palani Kirubakaran , Karthikeyan Muthusamy ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2012, Vol.21 (8), pp.2105-2116Springer
摘要:Abstract(#br)Carbamate kinase catalyzes the reversible reaction of carbamoyl phosphate, ADP to ATP and ammonium phosphate which is then hydrolyzed to ammonia and carbonate. In this study, the three-dimensional model of TvCK has been constructed by molecular modeling studies....
作者:Palani Kirubakaran , Karthikeyan Muthusamy ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2013, Vol.22 (8), pp.3812-3822Springer
摘要:Abstract(#br)The 3-phosphoinositide-dependent protein kinase-1 (PDK1) is an imminent target for discovering novel anticancer drugs. In order to understand the structure–activity correlation of naphthyridine-based PDK-1 inhibitors, we have carried out a combined pharmacophore...
作者:Palani Kirubakaran , Kh Dhanachandra Singh
来源:[J].Medicinal Chemistry Research(IF 1.612), 2012, Vol.21 (9), pp.2169-2180Springer
摘要:Abstract(#br)Biotin carboxylase (AccC) protein plays an essential role in cell wall biosynthesis in majority of bacterial genera. Inhibition of cell wall biosynthesis might be an ideal way to control the bacterial multiplication in the host system. AccC is one of the promisi...
作者:Palani Kirubakaran , Muthusamy Karthikeyan ...
来源:[J].Journal of Molecular Modeling(IF 1.984), 2013, Vol.19 (1), pp.407-419Springer
摘要:Abstract(#br)Over expression of T-lymphokine–activated killer cell–originated protein kinase (TOPK) has been associated with leukemia, myeloma tumors and various other cancers. The function and regulatory mechanism of TOPK in tumor cells remains unclear. Structural studies t...
作者:Palani Kirubakaran , S. Manikandaprabhu ...
来源:[J].Indian Journal of Microbiology(IF 0.457), 2012, Vol.52 (1), pp.28-34Springer
摘要:Abstract(#br)Yellow fever virus (YFV) is caused by single stranded positive RNA virus called Flavivirus. Till now no specific antiviral agents are available for the treatment of YFV, and despite a commercial YFV vaccine, there are still approximately 30,000 deaths worldwide each ...
作者:Palani Kirubakaran , Shanthi Nagarajan ...
来源:[J].Journal of Molecular Modeling(IF 1.984), 2012, Vol.18 (1), pp.39-51Springer
摘要:Abstract(#br)To date, no suitable vaccine or specific antiviral drug is available to treat Chikungunya viral (CHIKV) fever. Hence, it is essential to identify drug candidates that could potentially impede CHIKV infection. Here, we present the development of a homology model ...
作者:... Muthusamy Karthikeyan , Palani Kirubakaran , Selvaraman Nagamani
来源:[J].Journal of Molecular Graphics and Modelling(IF 2.325), 2011, Vol.30, pp.186-197Elsevier
摘要:Abstract(#br)Janus kinase 2 (JAK2) plays a crucial role in the patho-mechanism of cardiovascular pathologies, myeloproliferative disorders and many other diseases. Thus, effective JAK2 kinase inhibitors may be of significant therapeutic importance. In this study, a pharmacophore ...

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