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作者:... Antonio Di Zazzo , Stefano Bonini , Pablo Argüeso
来源:[J].Scientific Reports(IF 2.927), 2020, Vol.10 (Pt 1), pp.785-799Springer
摘要:Abstract(#br)A growing body of evidence implicates endoplasmic reticulum (ER) stress in the pathogenesis of chronic inflammatory and autoimmune disorders. Here, we demonstrate that the proinflammatory cytokine TNFα stimulates matrix metalloproteinase 9 (MMP9) at the ocular s...
作者:Pablo Argüeso , Tom Eirik Mollnes ...
来源:[J].Acta Biomaterialia(IF 5.093), 2019, Vol.96, pp.330-344Elsevier
摘要:Abstract(#br)To address the shortcomings associated with corneal transplants, substantial efforts have been focused on developing new modalities such as xenotransplantion. Xenogeneic corneas are anatomically and biomechanically similar to the human cornea, yet their applications ...
作者:Pablo Argüeso , José Aijón ...
来源:[J].The Ocular Surface(IF 2.643), 2019, Vol.17 (2), pp.285-294Elsevier
摘要:Abstract(#br)Purpose(#br)To evaluate the therapeutic effect of subconjunctival injection of human mesenchymal stromal cells (hMSCs) in the cornea of mice with graft versus host disease (GVHD).(#br)Methods(#br)GVHD was induced in mice after hematopoietic stem cell transplantation ...
作者:... Reza Dana , Flavio Mantelli , Pablo Argüeso
来源:[J].American Journal of Ophthalmology(IF 3.631), 2015, Vol.159 (6), pp.1027-1035.e3Elsevier
摘要:Purpose(#br)To investigate the expression, release, and proteolytic degradation of galectin-3 in patients with dry eye disease.(#br)Design(#br)Observational case series with a comparison group.(#br)Methods(#br)Tear washes and conjunctival impression cytology specimens were c...
作者:Ilene K. Gipson , Yuichi Hori , Pablo Argüeso
来源:[J].The Ocular Surface(IF 2.643), 2004, Vol.2 (2), pp.131-148Elsevier
摘要:Abstract(#br)At the ocular surface, three types of mucins are present. The large gel-forming mucin MUC5AC is expressed by conjunctival goblet cells. Some cells of the lacrimal gland acini express the small soluble mucin MUC7. The corneal and conjunctival epithelia express th...
作者:Ana Guzman-Aranguez , Pablo Argüeso
来源:[J].The Ocular Surface(IF 2.643), 2010, Vol.8 (1), pp.8-17Elsevier
摘要:Abstract(#br)Mucins are major components in mucus secretions and apical cell membranes on wet-surfaced epithelia. Structurally, they are characterized by the presence of tandem repeat domains containing heavily O-glycosylated serine and threonine residues. O-glycans contribute to...
作者:Yuichi Uchino , Ashley M. Woodward , Pablo Argüeso
来源:[J].Experimental Eye Research(IF 3.026), 2016, Vol.153, pp.1-7Elsevier
摘要:Abstract(#br)Mucins are a group of highly glycosylated glycoproteins responsible for the protection of wet-surfaced epithelia. Recent data indicate that transmembrane mucins differ in their contribution to the protective function of the ocular surface, with MUC16 being the most e...
作者:Pablo Argüeso
来源:[J].Eye & Contact Lens: Science & Clinical Practice(IF 1.461), 2020, Vol.46 Suppl 2, pp.S53-S56Wolters Kluwer
摘要:ABSTRACT:: The glycocalyx is a dense and diverse coat of glycans and glycoconjugates responsible for maintaining cell surface integrity and regulating the interaction of cells with the external environment. Transmembrane mucins such as MUC1 and MUC16 comprise a major component of...

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