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作者:C. H. Ohlmann , P. Thelen
来源:[J].Der Urologe(IF 0.456), 2017, Vol.56 (4), pp.465-471
摘要:Die Androgenentzugstherapie stellt weiterhin den Standard in der Therapie des Prostatakarzinoms dar, sowohl als primärer Androgenentzug als auch mit sekundären antihormonellen Therapien wie Abirateron und Enzalutamid. Vor allem die klinisch häufig nicht evidenten Nebenwirkun...
作者:... C. Becker , P. Thelen , F. C. Roos
来源:[J].Der Urologe(IF 0.456), 2017, Vol.56 (9), pp.1164-1167
摘要:Androgenrezeptorspleißvarianten weisen im Gegensatz zum normalen Androgenrezeptor keine funktionsfähige Ligandenbindungsdomäne auf und tragen damit zur Entwicklung eines metastasierten kastrationsresistenten Prostatakarzinoms bei, das pharmakologisch nicht mehr durch Androge...
作者:... L. Trojan , J. Meller , P. Thelen
来源:[J].EJNMMI Research, 2015, Vol.5 (1), pp.1-11
摘要:Abstract(#br) Background(#br)Prostate-specific membrane antigen (PSMA) is a promising target for diagnostics and therapy of prostate carcinoma (PCa). Based on the hypothesis that PSMA expression can be modulated by variations in androgen deprivation therapy (ADT), we investi...
作者:P. THELEN , W. WUTTKE ...
来源:[J].The Journal of Urology(IF 3.696), 2004, Vol.171 (5), pp.1934-1938
摘要:ABSTRACT(#br)Purpose(#br)The androgen sensitive prostate cancer cell line LNCaP is strongly positive for dihydrotestosterone (DHT) dependent telomerase activity, which is an important factor in cellular immortality and carcinogenesis. In this study we determined the potentia...
作者:M. Böttner , P. Thelen , H. Jarry
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2014, Vol.139, pp.245-251
摘要:Abstract(#br)In 1996, the molecular biology of E2 had to be reevaluated: in an effort to identify novel nuclear receptors or unknown isoforms of existing receptors Kuiper and colleague described the expression of a novel subtype of the estrogen receptor (ER) in rat prostate ...
作者:... L. Pitzel , P. Thelen , W. Wuttke
来源:[J].Maturitas(IF 2.844), 2006, Vol.55, pp.S75-S82
摘要:Abstract(#br)Objectives(#br)Prostate cancers and many thereof derived cell lines, as the LNCaP cells, grow androgen-dependent. In vivo testosterone is locally converted by 5α-reductase to 5α-dihydrotestosterone (5α-DHT) which is the major androgenic principle in prostates an...
作者:P. THELEN , M. KALLERHOFF ...
来源:[J].The Journal of Urology(IF 3.696), 1998, Vol.160 (5), pp.1914-1918
摘要:Abstract(#br)Degradation of the extracellular matrix is necessary for invasion and metastasis by cancer cells. Two gelatinolytic matrix metalloproteinase enzymes, MMP-2 and MMP-9, are supposed to be key enzymes in this process. The purpose of this study was to correlate the prese...
作者:P. Thelen , V. Christoffel ...
来源:[J].Phytomedicine(IF 2.972), 2004, Vol.12 (3), pp.178-182
摘要:Abstract(#br)Extracts from black cohosh ( Cimicifuga racemosa , CR) exert an anti-proliferative action in human breast cancer cell cultures, which has been attributed to an anti-estrogenic effect. However, CR constituents do not bind to either of the known estrogen receptors...

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