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作者:... S R Tew , E G Canty-Laird , P D Clegg
来源:[J].Eur Cell Mater(IF 4.558), 2019, Vol.38, pp.123-136
摘要:The main challenge in tendon injury management is suboptimal tissue healing that fails to re-establish original tendon function. Tissue bioengineering is a promising approach for tendon therapy, with potential to improve its functional outcomes. However, evaluation criteria for t...
作者:... E J Comerford , P D Clegg , E G Canty-Laird
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.35, pp.87-102
摘要:BiTendons are constructed from collagenous fascicles separated by endotenon/interfascicular matrix (IFM). Tendons may be specialised for precision movement or to store energy during locomotion and for the latter the elasticity of the endotenon/IFM is particularly important. The e...
作者:... J Loughlin , C Proctor , P D Clegg
来源:[J].Eur Cell Mater(IF 4.558), 2016, Vol.31, pp.136-159
摘要:Mesenchymal stem cells (MSC) are capable of multipotent differentiation into connective tissues and as such are an attractive source for autologous cell-based treatments for many clinical diseases and injuries. Ageing is associated with various altered cellular phenotypes coupled...
作者:... B McDermott , G L Pinchbeck , P D Clegg
来源:[J].Eur Cell Mater(IF 4.558), 2011, Vol.21, pp.470-478
摘要:Arthropathy of the distal articular surfaces of the third metacarpal (Mc3) and metatarsal (Mt3) bones in the Thoroughbred racehorse (Tb) is a natural model of repetitive overload arthrosis. We describe a novel pathology that affects the articular calcified cartilage (ACC) and sub...
作者:... H L Birch , P D Clegg , H RC Screen
来源:[J].Eur Cell Mater(IF 4.558), 2013, Vol.25, pp.48-60
摘要:Age-related tendinopathy is common in both humans and horses; the initiation and progression of which is similar between species. The majority of tendon injuries occur to high-strain energy storing tendons, such as the human Achilles tendon and equine superficial digital flexor (...

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