全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Oreekha Amin , Joanna Bitharas ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:Phosphatase and Tensin homolog (PTEN) is a tumor suppressor gene. Loss of its function is the most frequent genetic alteration in endometrioid endometrial cancers (70–80%) and high grade tumors (90%). We assessed the sensitivity of endometrial cancer cell lines to PARP inhib...
作者:Oreekha Amin , Marie-Claude Beauchamp ...
来源:[J].BMC Cancer(IF 3.333), 2015, Vol.15 (1)Springer
摘要:Abstract(#br) Background(#br)Impairment of homologous recombination (HR) is found in close to 50 % of ovarian and breast cancer. Tumors with BRCA1 mutations show increased expression of the Insulin-like growth factor type 1 receptor (IGF-1R). We previously have shown that inhibit...
作者:Oreekha Amin , Joanna Bitharas ...
来源:[J].2017, Vol.17 (1), pp.638BMC
摘要:Phosphatase and Tensin homolog (PTEN) is a tumor suppressor gene. Loss of its function is the most frequent genetic alteration in endometrioid endometrial cancers (70–80%) and high grade tumors (90%). We assessed the sensitivity of endometrial cancer cell lines to PARP inhib...
作者:Oreekha Amin , Marie-Claude Beauchamp ...
来源:[J].2015, Vol.15 (1), pp.817BMC
摘要:Impairment of homologous recombination (HR) is found in close to 50 % of ovarian and breast cancer. Tumors with BRCA1 mutations show increased expression of the Insulin-like growth factor type 1 receptor (IGF-1R). We previously have shown that inhibition of IGF-1R results in...
作者:Oreekha Amin , Charles-Andre Philip ...
来源:[J].International Journal of Gynecological Cancer(IF 1.941), 2016, Vol.26 (7), pp.1213-1221Wolters Kluwer
摘要:PURPOSE: Epithelial-mesenchymal transition (EMT) is a critical process for cancer metastasis and recurrence. Metformin, an effective oral antidiabetic drug, has been associated with decreased cancer risk and mortality. In this pilot study, we started to evaluate the effect of met...

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