全部文献期刊会议图书|学者科研项目
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作者:Jana Kubackova , Jarmila Zbytovska , Ondrej Holas
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2020, Vol.142
摘要:Abstract(#br)The potential of nanotechnology has been explored throughout fields of medicine and found its application also in immunology. Given the crucial defence role and disseminated character of the immune system, the idea of using its strength in treatment has always been v...
作者:Ondrej Holas , Alzbeta Horvatova ...
来源:[J].Toxicology Letters(IF 3.145), 2019, Vol.313, pp.1-10
摘要:Abstract(#br)The constitutive androstane receptor(CAR) activation is connected with mitogenic effects leading to liver hyperplasia and tumorigenesis in rodents. CAR activators, including phenobarbital, are considered rodent non-genotoxic carcinogens. Recently, trans -3,4,5,4...
作者:Ondrej Holas , Miroslav Pohanka ...
来源:[J].International Journal of Biological Macromolecules(IF 2.596), 2014, Vol.70, pp.435-439
摘要:Abstract(#br)A new series of substituted tacrine/acridine and tacrine/tacrine dimers with aliphatic or alkylene-thiourea linkers was synthesized and the potential of these compounds as novel human acetylcholinesterase ( h AChE) and human butyrylcholinesterase ( h BChE) inhib...
作者:Ondrej Holas , Anna Horova ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2010, Vol.19 (2), pp.754-762
摘要:Abstract(#br)The treatment of organophosphorus (OP) poisoning consists of the administration of a parasympatholytic agent (e.g., atropine), an anticonvulsant (e.g., diazepam) and an acetylcholinesterase (AChE) reactivator (e.g., obidoxime). The AChE reactivator is the causal...
作者:Ondrej Holas , Jiri Binder ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2010, Vol.20 (20), pp.6093-6095
摘要:Abstract(#br)All approved drugs for Alzheimer disease (AD) in clinical practice ameliorate the symptoms of the disease. Among them, acetylcholinesterase inhibitors (AChEIs) are used to increase the cholinergic activity. Among new AChEI, tacrine compounds were found to be mor...
作者:Ondrej Holas , Martina Hrabinova ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2010, Vol.46 (2), pp.811-818
摘要:Abstract(#br)Inhibitors of acetylcholinesterase are compounds widely used in the treatment of various diseases, such as Alzheimer’s disease, glaucoma and Myasthenia gravis (MG). Compounds used in the therapy of MG posses a positive charge in the molecule to ensure peripheral...
作者:Ondrej Holas , Jan Korabecny
来源:[J].Talanta(IF 3.498), 2009, Vol.81 (1), pp.621-624
摘要:Abstract(#br)A dipstick for fast assay of nerve agents and organophosphate pesticides was developed. Indicator pH papers were used as detectors. The principle of the assay is based on enzymatic hydrolysis of acetylcholine into acetic acid and choline by acetylcholinesterase....
作者:Ondrej Holas , Eugenie Nepovimova ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2011, Vol.21 (21), pp.6563-6566
摘要:Abstract(#br)Cholinesterase inhibitors are, so far, the only successful strategy for the symptomatic treatment of Alzheimer’s disease. Tacrine (THA) is a potent acetylcholinesterase inhibitor that was used in the treatment of Alzheimer’s disease for a long time. However, the...
作者:Ondrej Holas , Daniel Jun ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2007, Vol.15 (21), pp.6733-6741
摘要:Abstract(#br)Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Fifteen new monooxime reactivators of acetylcholinesterase with a ( E )-but-2-ene linker were developed in an effort to extend the properties of K-oxime ( E )-1...

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