全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Masayuki Matsumoto , Okihide Hikosaka
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (10)DOAJ
摘要:The lateral habenula (LHb) is a brain structure which represents negative motivational value. Neurons in the LHb are excited by unpleasant events such as reward omission and aversive stimuli, and transmit these signals to midbrain dopamine neurons which are involved in learning a...
作者:... Kathryn M. Wall , Okihide Hikosaka , Okihide Hikosaka
来源:[J].Frontiers in Neuroanatomy(IF 4.058), 2017, Vol.11DOAJ
摘要:Anatomically distinct areas within the basal ganglia encode flexible- and stable-value memories for visual objects (Hikosaka et al., 2014), but an important question remains: do they receive inputs from the same or different brain areas or neurons? To answer this question, we fir...
作者:Hyoung F. Kim , Ali Ghazizadeh , Okihide Hikosaka
来源:[J].Cell(IF 31.957), 2015, Vol.163 (5), pp.1165-1175Elsevier
摘要:Summary(#br)Dopamine neurons promote learning by processing recent changes in reward values, such that reward may be maximized. However, such a flexible signal is not suitable for habitual behaviors that are sustained regardless of recent changes in reward outcome. We discov...
作者:Okihide Hikosaka , Shinya Yamamoto ...
来源:[J].Trends in Cognitive Sciences(IF 16.008), 2013, Vol.17 (9), pp.434-441Elsevier
摘要:Maximizing rewards per unit time is ideal for success and survival in humans and animals. This goal can be approached by speeding up behavior aiming at rewards and this is done most efficiently by acquiring skills. Importantly, reward-directed skills consist of two component...
作者:Hyoung F. Kim , Okihide Hikosaka
来源:[J].Neuron(IF 15.766), 2013, Vol.79 (5), pp.1001-1010Elsevier
摘要:Summary(#br)Choosing valuable objects is critical for survival, but their values may change flexibly or remain stable. Therefore, animals should be able to update the object values flexibly by recent experiences and retain them stably by long-term experiences. However, it is uncl...
作者:Okihide Hikosaka , David A. Leopold
来源:[J].Journal of Neuroscience Methods(IF 2.114), 2013, Vol.213 (1), pp.123-131Elsevier
摘要:Abstract(#br)Neurophysiologists want to place the tip of an electrode in a specific area of the brain. The coordinates of this area can be obtained from standard stereotaxic atlases. However, individual brains may not align with the atlas exactly. Additionally, for chronic record...
作者:Yoshihisa Tachibana , Okihide Hikosaka
来源:[J].Neuron(IF 15.766), 2012, Vol.76 (4), pp.826-837Elsevier
摘要:Summary(#br)Motor actions are facilitated when expected reward value is high. It is hypothesized that there are neurons that encode expected reward values to modulate impending actions and potentially represent motivation signals. Here, we present evidence suggesting that the ven...
作者:Hiroyuki Nakahara , Okihide Hikosaka
来源:[J].Neuroscience Research(IF 2.204), 2012, Vol.74 (3-4), pp.177-183Elsevier
摘要:Abstract(#br)Predicting outcomes is a critical ability of humans and animals. The dopamine reward prediction error hypothesis, the driving force behind the recent progress in neural “value-based” decision making, states that dopamine activity encodes the signals for learning...
作者:... Hideki Fukuda , Yoshikazu Ugawa , Okihide Hikosaka
来源:[J].Clinical Neurophysiology(IF 3.144), 2013, Vol.124 (8), pp.1491-1506Elsevier
摘要:Abstract(#br)We reviewed basal ganglia (BG) dysfunction in Parkinson’s disease (PD) based on recent findings on saccade performance. Hypometria in all saccade paradigms and impaired initiation of internally triggered saccades such as memory guided saccades (MGS) are reported...

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