全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Octavio Moldes , Tomás Sobrino ...
来源:[J].Neuropharmacology(IF 4.114), 2012, Vol.63 (8), pp.1279-1285Elsevier
摘要:Abstract(#br)Endothelin-1 (ET-1) is involved on the development of cerebral edema in acute ischemic stroke. As edema is a therapeutic target in cerebral ischemia, our aim was to study the effect of antagonists for ET-1 receptors (Clazosentan ® and BQ-788, specific antagonist...
作者:Octavio Moldes , José Castillo
来源:[J].Atherosclerosis(IF 3.706), 2013, Vol.226 (1), pp.165-171Elsevier
摘要:Abstract(#br)Objective(#br)Platelet derived growth factor-CC (PDGF–CC) isoform is activated by tissue plasminogen activator (tPA) regulating blood brain barrier permeability after ischemia. We aimed to study the association of PDGF isoforms serum levels with hemorrhagic tran...
作者:Octavio Moldes , Jesús Agulla ...
来源:[J].Clinical Chemistry and Laboratory Medicine(IF 3.009), 2009, Vol.47 (12), pp.1513-1518De Gruyter
摘要:Abstract Background : Neuron-specific enolase (NSE) and S100 protein are implicated in several brain injuries, including stroke. Our objective was to analyze the temporal profile and the clinical significance of NSE and S-100 in acute ischemic (IS) and intracerebral hemorrha...
作者:Octavio Moldes , Susana Arias ...
来源:[J].Journal of Cerebral Blood Flow & Metabolism(IF 5.398), 2011, Vol.31 (6), pp.1424-1431Sage国际出版集团
摘要:Stroke triggers an intense inflammatory response that could be a consequence of Toll-like receptors (TLRs) activation. However, the clinical significance and the therapeutic possibilities of TLR in stroke is not completely clear. In this study, we analyze the association bet...
作者:Octavio Moldes , Tomás Sobrino ...
来源:[J].Stroke(IF 6.158), 2008, Vol.39 (7), pp.2006-2010Wolters Kluwer
摘要:BACKGROUND AND PURPOSE—: Severe cerebral edema is associated with poor outcome in patients with acute stroke. Experimental studies suggest that astrocytic endothelin-1 (ET-1) has deleterious effects on water homeostasis, cerebral edema, and blood brain barrier (BBB) integrit...

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