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作者:... Matthieu Duchmann , Nolwenn Lucas , Eric Solary
来源:[J].International Journal of Hematology(IF 1.681), 2017, Vol.105 (6), pp.711-719
摘要:Chronic Myelomonocytic Leukemia is a chronic myeloid neoplasm occurring mostly in the elderly with overlapping features of myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) characterized by chronic monocytosis. Recent progresses in the molecular and cellular ...
作者:Nolwenn Lucas , Sylvain Pilorge ...
来源:[J].Clinical Lymphoma, Myeloma and Leukemia(IF 1.667), 2019
摘要:Abstract(#br)Allogeneic hematopoietic cell transplantation (AHCT) represents the only curative therapy for many hematological malignancies. The graft versus leukemia effect, driven by donor T cells, plays a major role in its curative potential. This effect is sometimes very evide...
作者:Nolwenn Lucas , Joanna Quinn ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2012, Vol.22 (7), pp.2620-2623
摘要:Abstract(#br)A series of novel benzimidazoles are discussed as NR2B-selective N -methyl- d -aspartate (NMDA) receptor antagonists. High throughput screening (HTS) efforts identified a number of potent and selective NR2B antagonists such as 1 . Exploration of the substituents arou...
作者:Nolwenn Lucas , Vincent Parinet ...
来源:[J].Leukemia & Lymphoma(IF 2.301), 2017, Vol.58 (12), pp.2875-2879
摘要:Abstract(#br)Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic disorder that associates dysplastic and proliferative features. Tissue inflammatory disorders occur in a fraction of CMML patients during the course of their disease. Here, we describe the occurrence of...
作者:Nolwenn Lucas , Matthieu Duchmann ...
来源:[J].Leukemia(IF 10.164), 2019, Vol.33 (2), pp.2466-2480
摘要:Abstract(#br)Islands of CD123high cells have been commonly described in the bone marrow of patients with chronic myelomonocytic leukemia (CMML). Using a multiparameter flow cytometry assay, we detected an excess of CD123+ mononucleated cells that are li...
作者:Nolwenn Lucas , Jun-Min Zhou ...
来源:[J].Leukemia(IF 10.164), 2019, Vol.33 (1), pp.205-216
摘要:Abstract(#br)Chronic myelomonocytic leukemia (CMML) is a clinically heterogeneous neoplasm in which JAK2 inhibition has demonstrated reductions in inflammatory cytokines and promising clinical activity. We hypothesize that annotation of inflammatory cytokines may uncover mut...

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