全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Peter Schraml , Holger Moch , Niko Beerenwinkel
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:Next-generation sequencing of matched tumor and normal biopsy pairs has become a technology of paramount importance for precision cancer treatment. Sequencing costs have dropped tremendously, allowing the sequencing of the whole exome of tumors for just a fraction of the total tr...
作者:... Amnon Sonnenberg , Niko Beerenwinkel , Benjamin Misselwitz
来源:[J].BMC Medical Informatics and Decision Making(IF 1.603), 2017, Vol.17 (1)Springer
摘要:Colorectal cancer (CRC) is a leading cause of cancer-related mortality. CRC incidence and mortality can be reduced by several screening strategies, including colonoscopy, but randomized CRC prevention trials face significant obstacles such as the need for large study populations ...
作者:... Ewa Szczurek , Thomas Sakoparnig , Niko Beerenwinkel
来源:[J].Genome Medicine(IF 3.397), 2017, Vol.9 (1)Springer
摘要:Establishing the cancer type and site of origin is important in determining the most appropriate course of treatment for cancer patients. Patients with cancer of unknown primary, where the site of origin cannot be established from an examination of the metastatic cancer cells, ty...
作者:Niko Beerenwinkel , Huldrych F Günthard
来源:[J].PLoS ONE(IF 3.73), 2018, Vol.8 (9)DOAJ
摘要:Next-generation sequencing (NGS) is a valuable tool for the detection and quantification of HIV-1 variants in vivo. However, these technologies require detailed characterization and control of artificially induced errors to be applicable for accurate haplotype reconstruction. To ...
作者:... Arnab Bhattacharya , Nicholas Eriksson , Niko Beerenwinkel
来源:[J].BMC Bioinformatics(IF 3.024), 2011, Vol.12 (1)Springer
摘要:Abstract(#br) Background(#br)With next-generation sequencing technologies, experiments that were considered prohibitive only a few years ago are now possible. However, while these technologies have the ability to produce enormous volumes of data, the sequence reads are prone to e...
作者:... Martin Däumer , Christian Beisel , Niko Beerenwinkel
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (10)DOAJ
摘要:Recent advancements of sequencing technology have opened up unprecedented opportunities in many application areas. Virus samples can now be sequenced efficiently with very deep coverage to infer the genetic diversity of the underlying virus populations. Several sequencing platfor...
作者:Niko Beerenwinkel , Diane E Dickel ...
来源:[J].PLoS Computational Biology(IF 5.215), 2017, Vol.13 (8)DOAJ
摘要:Epigenomic mapping of enhancer-associated chromatin modifications facilitates the genome-wide discovery of tissue-specific enhancers in vivo. However, reliance on single chromatin marks leads to high rates of false-positive predictions. More sophisticated, integrative methods hav...
作者:... Urs Greber , Holger Fröhlich , Niko Beerenwinkel
来源:[J].PLoS Computational Biology(IF 4.867), 2015, Vol.11 (4)DOAJ
摘要:Nested effects models have been used successfully for learning subcellular networks from high-dimensional perturbation effects that result from RNA interference (RNAi) experiments. Here, we further develop the basic nested effects model using high-content single-cell imaging data...
作者:... Jimmy Lin , Bert Vogelstein , Niko Beerenwinkel
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (11)DOAJ
摘要:Cancer evolves through the accumulation of mutations, but the order in which mutations occur is poorly understood. Inference of a temporal ordering on the level of genes is challenging because clinically and histologically identical tumors often have few mutated genes in common. ...
作者:... Alejandro A Schäffer , Niko Beerenwinkel , Manoj B Mahimkar
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (2)DOAJ
摘要:Identifying oral cancer lesions associated with high risk of relapse and predicting clinical outcome remain challenging questions in clinical practice. Genomic alterations may add prognostic information and indicate biological aggressiveness thereby emphasizing the need for genom...

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