全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Niklas Mattsson , Josef Pannee ...
来源:[J].Molecular Neurodegeneration(IF 4.007), 2017, Vol.12 (1)Springer
摘要:Proteolytic degradation of amyloid β (Aβ) peptides has been intensely studied due to the central role of Aβ in Alzheimer’s disease (AD) pathogenesis. While several enzymes have been shown to degrade Aβ peptides, the main pathway of Aβ degradation in vivo is unknown. Cer...
作者:... Kaj Blennow , Henrik Zetterberg , Niklas Mattsson
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:Surgery and anesthesia have been linked to postoperative cognitive disturbance and increased risk of Alzheimer’s disease. It is not clear by which mechanisms this increased risk for cognitive disease is mediated. Further, amyloid β production has been suggested to depend on ...
作者:Niklas Mattsson , Philip Insel ...
来源:[J].PLoS ONE(IF 3.73), 2018, Vol.8 (12)DOAJ
摘要:Cerebrospinal fluid (CSF) α-synuclein is reduced in synucleinopathies, including dementia with Lewy bodies, and some studies have found increased CSF α-synuclein in Alzheimer's disease (AD). No study has explored effects of CSF α-synuclein on brain atrophy. Here we tested if...
作者:Niklas Mattsson , Sebastian Palmqvist
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (1), pp.1-9DOAJ
摘要:Abstract The independent effects of different brain pathologies on age-dependent cognitive decline are unclear. We examined this in 300 cognitively unimpaired elderly individuals from the BioFINDER study. Using cognition as outcome we studied the effects of cerebrospinal flu...
作者:Niklas Mattsson , Clifford R. Jack ...
来源:[J].The American Journal of Geriatric Psychiatry(IF 4.131), 2016, Vol.24 (2), pp.126-135Elsevier
摘要:Objective(#br)Investigate the association of chronic depressive symptomatology (chrDS) with cortical atrophy rates and conversion to Alzheimer dementia (AD) over 3 years in mild cognitive impairment (MCI).(#br)Methods(#br)In a multicenter, clinic-based study, MCI elderly par...
作者:... Danielle van Westen , Niklas Mattsson , Oskar Hansson
来源:[J].Neurobiology of Aging(IF 6.166), 2019Elsevier
摘要:Abstract(#br)In this study, we investigated associations between neuropsychiatric symptoms (i.e., apathy, anxiety, and depression) and cerebral atrophy, white matter lesions (WML), beta-amyloid (Aβ) deposition, and cognitive decline in a nondemented sample. 104 cognitively u...

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