全部文献期刊会议图书|学者科研项目
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作者:Nicole S. Spoelstra , Diana M. Cittelly ...
来源:[J].Human Pathology(IF 2.843), 2016, Vol.56, pp.40-51
摘要:Summary(#br)Dicer is an RNase III enzyme responsible for cleaving double-stranded RNAs into small interfering RNAs and microRNAs, which either target messenger RNA transcripts for degradation or inhibit translation. Dicer protein levels have been examined in breast cancer wi...
作者:Nicole S. Spoelstra , Katerina J. Kechris ...
来源:[J].Journal of Investigative Dermatology(IF 6.193), 2015, Vol.135 (8), pp.2068-2076
摘要:In vitiligo, the autoimmune destruction of epidermal melanocytes produces white spots that can be repigmented by melanocyte precursors from the hair follicles, following stimulation with UV light. We examined by immunofluorescence the distribution of melanocyte markers (C-KIT, DC...
作者:Dawn R. Cochrane , Nicole S. Spoelstra , Jennifer K. Richer
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2012, Vol.357 (1-2), pp.50-59
摘要:Abstract(#br)Small non-coding RNAs termed microRNAs (miRNAs) are mediators of post-transcriptional gene silencing and are involved in all aspects of cell biology. Progesterone receptors (PR) are intimately involved in the normal physiology and diseases of hormone responsive tissu...
作者:Nicole S. Spoelstra , John D. Norris ...
来源:[J].Hormones and Cancer, 2017, Vol.8 (2), pp.69-77
摘要:Abstract(#br)Triple-negative breast cancer (TNBC) has a faster rate of metastasis compared to other breast cancer subtypes, and no effective targeted therapies are currently FDA-approved. Recent data indicate that the androgen receptor (AR) promotes tumor survival and may serve a...
作者:Nicole S. Spoelstra , Elaine M. Reno ...
来源:[J].Fertility and Sterility(IF 4.174), 2008, Vol.91 (6), pp.2650-2663
摘要:Objective(#br)To identify differentially expressed genes between fibroid and adjacent normal myometrium in an identical hormonal and genetic background.(#br)Design(#br)Array analysis of three leiomyomata and matched adjacent normal myometrium in a single patient.(#br)Setting(#br)...
作者:Nicole S. Spoelstra , Meenakshi Singh ...
来源:[J].Breast Cancer Research and Treatment(IF 4.469), 2008, Vol.112 (3), pp.475-488
摘要:Abstract(#br)Approximately 30% of patients with estrogen receptor (ER) positive breast cancers exhibit de novo or intrinsic resistance to endocrine therapies. The purpose of this study was to define genes that distinguish ER+ resistant from ER+ responsive tumors, prior to th...
作者:Nicole S. Spoelstra , Erin L. McKinsey ...
来源:[J].Hormones and Cancer, 2010, Vol.1 (6), pp.306-319
摘要:Abstract(#br)To identify microRNAs (miRNAs) associated with estrogen receptor (ESR1) status, we profiled luminal A, ESR1+ breast cancer cell lines versus triple negative (TN), which lack ERα, progesterone receptor and Her2/neu. Although two thirds of the differentially expre...
作者:Nicole S. Spoelstra , Erin N. Howe ...
来源:[J].Hormones and Cancer, 2014, Vol.5 (6), pp.374-389
摘要:Abstract(#br)The anti-diabetic drug metformin (1,1-dimethylbiguanide hydrochloride) reduces both the incidence and mortality of several types of cancer. Metformin has been shown to selectively kill cancer stem cells, and triple-negative breast cancer (TNBC) cell lines are mo...

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