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作者:Nicole L. Moore , Adrienne R. Hanson ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2020, Vol.199
摘要:Abstract(#br)Medroxyprogesterone acetate (MPA) is a first generation progestin that has been in clinical use for various hormonal conditions in women since the 1960s. Although developed as a progesterone receptor (PR) agonist, MPA also has strong binding affinity for other s...
作者:Nicole L. Moore , Dean P. Edwards , Nancy L. Weigel
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2014, Vol.144, pp.471-482
摘要:Abstract(#br)A role for the cell cycle protein cyclin A2 in regulating progesterone receptor (PR) activity is emerging. This study investigates the role of cyclin A2 in regulating endogenous PR activity in T47D breast cancer cells by depleting cyclin A2 expression and measuring P...
作者:Nicole L. Moore , Nancy L. Weigel
来源:[J].International Journal of Biochemistry and Cell Biology(IF 4.152), 2011, Vol.43 (8), pp.1157-1167
摘要:Abstract(#br)We described previously a novel role for cyclin A2/Cdk2 as a progesterone receptor (PR) coactivator. In reporter gene assays, cyclin A2 overexpression enhanced PR activity while inhibition of Cdk2 activity using the chemical inhibitor roscovitine or Cdk2 siRNA strong...
作者:Nicole L. Moore , Ramesh Narayanan , Nancy L. Weigel
来源:[J].Steroids(IF 2.803), 2006, Vol.72 (2), pp.202-209
摘要:Abstract(#br)The function of the S phase kinase cyclin A/Cdk2 in maintaining and regulating cell cycle kinetics is well established. However an alternative role in the regulation of progesterone receptor (PR) signaling is emerging. PR and its coactivators are phosphoproteins. Cyc...
作者:Nicole L. Moore , Theresa E. Hickey ...
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2012, Vol.357 (1-2), pp.60-70
摘要:Abstract(#br)Synthetic progestins are used clinically to treat a variety of women’s health issues. Although progestins are designed to signal through the progesterone receptor (PR) to elicit specific pharmacological effects, they can also variably bind to and influence the a...
作者:Nicole L. Moore , Christine L. Clarke ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2007, Vol.110 (3), pp.236-243
摘要:Abstract(#br)Androgen signaling, mediated by the androgen receptor (AR), is a critical factor influencing growth of normal and malignant breast cells. Given the increasing use of exogenous androgens in women, a better understanding of androgen action in the breast is essenti...
作者:Nicole L. Moore , Shana Margolis ...
来源:[J].American Journal of Physical Medicine & Rehabilitation(IF 1.731), 2007, Vol.86 (6), pp.435-445
摘要:Kiebzak GM, Moore N, Margolis S, Hollis B, Kevorkian CG: Vitamin D status of patients admitted to a hospital rehabilitation unit: relationship to function and progress. Am J Phys Med Rehabil 2007;86:435–445. OBJECTIVE:: The primary objective was to determine the association ...
作者:Nicole L. Moore , Tanja Jankovic-Karasoulos ...
来源:[J].Menopause(IF 3.163), 2014, Vol.21 (1), pp.79-88
摘要:OBJECTIVE: Medroxyprogesterone acetate (MPA), a component of combined estrogen-progestin therapy (EPT), has been associated with increased breast cancer risk in EPT users. MPA can bind to the androgen receptor (AR), and AR signaling inhibits cell growth in breast tissues. Th...
作者:Nancy L. Weigel , Nicole L. Moore
来源:[J].Nuclear Receptor Signaling, 2007, Vol.5 (1)
摘要:Although the primary signal for the activation of steroid hormone receptors is binding of hormone, there is increasing evidence that the activities of cell signaling pathways and the phosphorylation status of these transcription factors and their coregulators determine the overal...

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