全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Nicolas Gouault , Philippe Uriac ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (4)DOAJ
摘要:Chagas' disease is caused by Trypanosoma cruzi, a protozoan transmitted to humans by blood-feeding insects, blood transfusion or congenitally. Previous research led us to discover a parasite proline racemase (TcPRAC) and to establish its validity as a target for the design of new...
作者:Nicolas Gouault , Nolwenn Oliviero ...
来源:[J].Fitoterapia(IF 2.231), 2019, Vol.137Elsevier
摘要:Abstract(#br)We have previously demonstrated that out of the butyrolactones series synthesized based on the natural lichen metabolite lichesterinic acid, compound ( B-13 ) was the most effective against oral bacteria. However, its antibacterial mechanism is still unknown. In this...
作者:... Jacques Renault , Philippe Uriac , Nicolas Gouault
来源:[J].J. Org. Chem., 2013, Vol.78 (16), pp.7809鈥?815ACS
摘要:(3) In this way, methods leading to such intermediates with strict control of regio- and stereochemistry continue to stand as a prominent objective in synthetic organic chemistry. ... The starting materials, the β-amino-ynones 1, were prepared from commercially available ami...
作者:... Myriam Le Roch , Michèle David , Nicolas Gouault
来源:[J].Tetrahedron: Asymmetry(IF 2.115), 2015, Vol.26 (15-16), pp.868-875Elsevier
摘要:Abstract(#br)A convenient gold-catalyzed asymmetric synthesis of polysubstituted furfurylamines starting from amino acids has been achieved. The cyclization proceeded under mild conditions and generally provided the furan or iodofuran derivatives in good to excellent yields and w...
作者:... Thierry Roisnel , Nicolas Gouault , Philippe Uriac
来源:[J].Tetrahedron Letters(IF 2.397), 2016, Vol.57 (27-28), pp.3036-3038Elsevier
摘要:Abstract(#br)Two types of indolizidine derivatives can be synthesized from amino-ynones. In the presence of methanesulfonic acid, Meyer–Schuster rearrangement furnished vinylogues of indolizidin-3-ones whereas treatment with zinc chloride gave stable 3-alkynyl-1,5,6,7,8,8 a ...
作者:... Joël Boustie , Bernard Pipy , Nicolas Gouault
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2014, Vol.24 (16), pp.3819-3822Elsevier
摘要:Abstract(#br)PPARγ and Nrf2 are important transcriptional factors involved in many signaling pathways, especially in the anti-infectious response of macrophages. Compounds bearing a Michael acceptor moiety are well known to activate such transcriptional factors, we thus eval...
作者:Nicolas Gouault , Jean-François Cupif ...
来源:[J].Tetrahedron Letters(IF 2.397), 2000, Vol.41 (38), pp.7293-7297Elsevier
摘要:Abstract(#br)The solid-phase synthesis of several γ-methyl-substituted-γ-butyrolactones using a cyclisation–cleavage reaction is reported. Chemical modifications of polymer-bound azido ( 2a ) and iodo alcohols ( 2b ) were realised in order to introduce additional diversity o...

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