全部文献期刊会议图书|学者科研项目
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作者:Nancy L Pedersen , Paul Lichtenstein ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (8)
摘要:Patterns of genetic diversity have previously been shown to mirror geography on a global scale and within continents and individual countries. Using genome-wide SNP data on 5174 Swedes with extensive geographical coverage, we analyzed the genetic structure of the Swedish populati...
作者:Nancy L Pedersen , Göran Hallmans ...
来源:[J].PLoS Genetics(IF 8.694), 2017, Vol.13 (6)
摘要:Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated rela...
作者:Nancy L Pedersen , David Cesarini ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (11)
摘要:Flow is a psychological state of high but subjectively effortless attention that typically occurs during active performance of challenging tasks and is accompanied by a sense of automaticity, high control, low self-awareness, and enjoyment. Flow proneness is associated with trait...
作者:Nancy L Pedersen , Terrance P O'Hanlon ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (9)
摘要:Although historically considered as junk-DNA, tandemly repeated sequence motifs can affect human phenotype. For example, variable number tandem repeats (VNTR) with embedded enhancers have been shown to regulate gene transcription. The post-zygotic variation is the presence o...
作者:Nancy L Pedersen , Patrick F Sullivan ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (12)
摘要:Twin registries around the globe have collected DNA samples from large numbers of monozygotic and dizygotic twins. The twin sample collections are frequently used as controls in disease-specific studies together with non-twins. This approach is unbiased under the hypothesis ...
作者:... Helena Nordenstedt , Nancy L Pedersen , Jesper Lagergren
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (10)
摘要:BACKGROUND & AIMS: Previous studies indicate an association between sleep problems and gastroesophageal reflux disease (GERD). Although both these conditions separately have moderate heritabilities, confounding by genetic factors has not previously been taken into account. This s...
作者:Nancy L Pedersen , Erik Ingelsson ...
来源:[J].Nature Genetics(IF 35.209), 2017, Vol.49 (8), pp.1174-1181
摘要:Matthew Robinson, Peter Visscher and colleagues use phenotypic data on 172,000 sibling pairs and phenotypic and SNP data on 150,832 unrelated individuals to estimate the heritability of body mass index across a range of experimental designs. They conclude that substantially ...
作者:Nancy L Pedersen , Lina Keller ...
来源:[J].PLoS Medicine(IF 16.269), 2015, Vol.12 (7)
摘要:Research has suggested that variations within the IDE/HHEX gene region may underlie the association of type 2 diabetes with Alzheimer disease (AD). We sought to explore whether IDE genes play a role in the association of diabetes with dementia, AD, and structural brain chang...
作者:Nancy L Pedersen , Erik Ingelsson ...
来源:[J].Nature Genetics(IF 35.209), 2015, Vol.47 (10), pp.1114-1120
摘要:Jian Yang and colleagues present a method, GREML-LDMS, to estimate heritability for complex human traits using whole-genome sequencing data or imputation with the 1000 Genomes Project reference panel. Using the heritability estimates from GREML-LDMS, they find that there is ...
作者:Nancy L Pedersen , Timothy D Spector ...
来源:[J].Nature Genetics(IF 35.209), 2015, Vol.47 (11), pp.1357-1362
摘要:Matthew Robinson and colleagues report an analysis of population genetic differences in human height and body mass index (BMI) across 14 European populations. They estimate the proportion of additive genetic variance attributable to population genetic differences and find ev...

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