全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Nagamani Selvaraman , Saravana Kumar Selvam , Karthikeyan Muthusamy
来源:[J].Chemical Biology & Drug Design(IF 2.469), 2016, Vol.88 (2), pp.272-280Wiley
摘要:Non‐secosteroidal ligands are well‐known vitamin D receptor (VDR) agonists. In this study, we described a combined QM / MM to define the protein–ligand interaction energy a strong positive correlation in both QM – MM interaction energy and binding free energy against th...
作者:Nagamani Selvaraman , Muthusamy Karthikeyan
来源:[J].PloS one(IF 3.73), 2018, Vol.13 (10), pp.e0203194PubMed
摘要:The level of the vitamin D in the bloodstream is regulated by cytochrome P450 enzyme 24-hydroxylase A1 (CYP24A1). Over expression of CYP24A1 enzyme is correlated with vitamin D deficiency and resistance to vitamin D therapy. Chronic kidney disease (CKD) patients are commonly...
作者:Nagamani Selvaraman , Kesavan Chandrasekhar , Muthusamy Karthikeyan
来源:[J].Combinatorial Chemistry & High Throughput Screening(IF 2), 2018, Vol.21 (5), pp.329-343IntechOpen
摘要:Aim and Objective: Vitamin D3 (1,25(OH)2D3) is a biologically active metabolite and plays a wide variety of regulatory functions in human systems. Currently, several Vitamin D analogues have been synthesized and tested against VDR (Vitamin D Receptor). Electrostatic potential met...
作者:... Chinnasamy Selvakkumar , Nagamani Selvaraman , Muthusamy Karthikeyan
来源:[J].Journal of biomolecular structure & dynamics, 2015, Vol.33 (7), pp.1516-27PubMed
摘要:Snake venom metalloproteinase (SVMP) (Echis coloratus (Carpet viper) is a multifunctional enzyme that is involved in producing several symptoms that follow a snakebite, such as severe local hemorrhage, nervous system effects and tissue necrosis. Because the three-dimensional...
作者:Nagamani Selvaraman , Singh Kh Dhanachandra , Muthusamy Karthikeyan
来源:[J].Meta gene, 2016, Vol.9, pp.26-36PubMed
摘要:FGF23, CYP24A1 and VDR altogether play a significant role in genetic susceptibility to chronic kidney disease (CKD). Identification of possible causative mutations may serve as therapeutic targets and diagnostic markers for CKD. Thus, we adopted both sequence and sequence-structu...
作者:Muthusamy Karthikeyan , Nagamani Selvaraman
来源:[J].Journal of molecular graphics & modelling, 2018, Vol.81, pp.14-24PubMed
摘要:Pharmacogenetics and pharmacogenomics have become presumptive with advancements in next-generation sequencing technology. In complex diseases, distinguishing the feasibility of pathogenic and neutral disease-causing variants is a time consuming and expensive process. Recent ...
作者:Nagamani Selvaraman , Kesavan Chandrasekhar , Muthusamy Karthikeyan
来源:[J].Combinatorial chemistry & high throughput screening, 2018, Vol.21 (5), pp.329-343PubMed
摘要:AIM AND OBJECTIVE(#br)Vitamin D3 (1,25(OH)2D3) is a biologically active metabolite and plays a wide variety of regulatory functions in human systems. Currently, several Vitamin D analogues have been synthesized and tested against VDR (Vitamin D Receptor). Electrostatic potential ...
作者:Nagamani Selvaraman , Muthusamy Karthikeyan
来源:[J].Pharmaceutical research, 2017, Vol.34 (7), pp.1444-1458PubMed
摘要:Over expression of ATP-binding cassette transporters is considered one of the major reasons for non-responsiveness to antiepileptic drugs. Carbamazepine (CBZ), one of first line antiepileptic drug is known to influence ABCC2 expression but its exact molecular mechanism is unknown...
作者:Nagamani Selvaraman , Tanneeru Karunakar ...
来源:[J].Journal of biomedical informatics, 2018, Vol.85, pp.114-125PubMed
摘要:Molecular Property Diagnostic Suite - Diabetes Mellitus (MPDSDM) is a Galaxy-based, open source disease-specific web portal for diabetes. It consists of three modules namely (i) data library (ii) data processing and (iii) data analysis tools. The data library (target library and ...
作者:Muthusamy Karthikeyan , Nagamani Selvaraman
来源:[J].Journal of molecular graphics & modelling, 2018, Vol.81, pp.14-24PubMed
摘要:Pharmacogenetics and pharmacogenomics have become presumptive with advancements in next-generation sequencing technology. In complex diseases, distinguishing the feasibility of pathogenic and neutral disease-causing variants is a time consuming and expensive process. Recent ...

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