全部文献期刊会议图书|学者科研项目
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作者:Muneyuki Sakata , Yasuhiko Ikari ...
来源:[J].European Journal of Nuclear Medicine and Molecular Imaging(IF 5.114), 2017, Vol.44 (5), pp.850-857
摘要:The aim of this study was to assess the inter-rater variability of the visual interpretation of 11C-PiB PET images regarding the positivity/negativity of amyloid deposition that were obtained in a multicenter clinical research project, Japanese Alzheimer’s Disease...
作者:Muneyuki Sakata , Jun Toyohara ...
来源:[J].Radiological Physics and Technology, 2017, Vol.10 (4), pp.422-430
摘要:The present study aimed to validate the effects of a novel tungsten-impregnated rubber neck shield on the quality of phantom and clinical 15O-labeled gas positron emission tomography (PET) images. Images were acquired in the presence or absence of a neck shield fr...
作者:Muneyuki Sakata , Jun Toyohara ...
来源:[J].Neurobiology of Aging(IF 6.166), 2017, Vol.55, pp.72-77
摘要:Abstract(#br)We examined possible age- and gender-related changes in binding of the selective antagonist N -[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4- 11 C-methoxy- N -methylbenzamide ( 11 C-ITMM) to metabotropic glutamate receptor type 1 in healthy human brains. ...
作者:Muneyuki Sakata , Keiichi Oda ...
来源:[J].Physica Medica(IF 1.167), 2017, Vol.42, pp.203-210
摘要:Abstract(#br)Purpose(#br)This study aimed to determine whether the SiPM-PET/CT, Discovery MI (DMI) performs better than the PMT-PET/CT system, Discovery 710 (D710).(#br)Methods(#br)The physical performance of both systems was evaluated using NEMA NU 2 standards. Contrast (%), uni...
作者:Muneyuki Sakata , Kenji Ishibashi ...
来源:[J].EJNMMI Research, 2017, Vol.7 (1), pp.1-9
摘要:Abstract(#br) Background(#br) N , N -di- n -propyl-2-[2-(4-[ 11 C]methoxyphenyl)-6,8-dichloroimidazol[1,2-a]pyridine-3-yl]acetamide ([ 11 C]CB184) is a novel selective radioligand for the 18-kD translocator protein (TSPO), which is upregulated in activated microglia in the b...
作者:Muneyuki Sakata , Kenji Ishii ...
来源:[J].Frontiers in Pharmacology, 2017, Vol.8
摘要:Adenosine A1 receptors (A1Rs) are widely distributed throughout the entire human brain, while adenosine A2A receptors (A2ARs) are present in dopamine-rich areas of the brain, such as the basal ganglia. A past study using autoradiography reported a reduced binding ability of ...
作者:Muneyuki Sakata , Makoto Hamamoto ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (2)
摘要:Adenosine A(2A) receptors (A2ARs) are thought to interact negatively with the dopamine D(2) receptor (D2R), so selective A2AR antagonists have attracted attention as novel treatments for Parkinson's disease (PD). However, no information about the receptor in living patients ...
作者:Muneyuki Sakata , Jin Wu ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.5 (2)
摘要:BACKGROUND: The alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease. The goal of this study was to evaluate the two carbon-11-labeled alpha7 nAChR agonists [(11)...

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