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作者:... Farid El-Hajbi , Franck Bonnetain , Mohamed Hebbar
来源:[J].Clinical Colorectal Cancer(IF 1.8), 2018, Vol.17 (1), pp.e99-e107
摘要:Abstract(#br)Background(#br)We studied the relationship between intermediate criteria and overall survival (OS) in metastatic colorectal cancer (mCRC) patients who received first-line chemotherapy with bevacizumab.(#br)Patients and Methods(#br)We assessed OS, progression-free sur...
作者:Mohamed Hebbar , Hemant M. Kocher ...
来源:[J].Pharmacology and Therapeutics(IF 7.793), 2018, Vol.181, pp.49-75
摘要:Abstract(#br)Until the 1990s, cytotoxic chemotherapy has been the cornerstone of medical therapy for gastrointestinal (GI) cancers. Better understanding of the cancer cell molecular biology has led to the therapeutic revolution of targeted therapies, i.e. monoclonal antibodies or...
作者:Mohamed Hebbar , Marine Hug de Larauze ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (6)
摘要:We previously showed that a sequential chemotherapy with dose-dense oxaliplatin (FOLFOX7) and irinotecan (FOLFIRI; irinotecan plus 5-fluorouracil/leucovorin) is not superior to FOLFOX4 in patients at advanced stage of colorectal cancer with liver metastases. Here we aimed to...
作者:Mohamed Hebbar , Céline Lepère ...
来源:[J].European Journal of Cancer(IF 5.061), 2016, Vol.68, pp.163-172
摘要:Abstract(#br)Background(#br)Early tumour shrinkage has been associated with improved survival in patients receiving cetuximab-based systemic chemotherapy for liver metastases from colorectal cancer (LM-CRC). We tested this hypothesis for previously treated LM-CRC patients re...
作者:Mohamed Hebbar , Antoine Adenis ...
来源:[J].European Journal of Cancer(IF 5.061), 2009, Vol.45 (10), pp.1871-1876
摘要:Abstract(#br)Some host-related factors may predict the risk of metastasis after surgery of colorectal cancer (CRC). The endothelial adhesion molecule E-selectin is implicated in the metastatic spread of CRC. We postulated that some polymorphisms within the E-selectin gene, e...
作者:Mohamed Hebbar , François-René Pruvot ...
来源:[J].Cancer Treatment Reviews(IF 6.024), 2009, Vol.35 (8), pp.668-675
摘要:Summary(#br)The liver is the primary metastatic site in patients with colorectal cancer, and the only hope for a cure or prolonged survival in patients with liver metastases is provided by surgical resection. Advances obtained in non-resectable metastatic disease using new c...
作者:Mohamed Hebbar , François René Pruvot ...
来源:[J].Journal of Surgical Research(IF 2.018), 2008, Vol.153 (2), pp.239-245
摘要:Background(#br)Expression of the principal initiator of coagulation, tissue factor (TF), by colorectal cancer (CRC) cells is involved in tumoral angiogenesis and metastasis progression, after binding of factor VIIa (FVIIa) to TF and generation of TF-FVIIa activity. We thus hypoth...
作者:Mohamed Hebbar , Tienhan Sandrine Dabakuyo ...
来源:[J].Journal of Hepatology(IF 9.858), 2013, Vol.58 (1), pp.81-88
摘要:Background & Aims(#br)The current standard treatment for advanced hepatocellular carcinoma (HCC) is sorafenib. This drug is effective but generally does not induce tumor shrinkage and other treatment options are still needed.(#br)Methods(#br)This retrospective multicenter st...
作者:Mohamed Hebbar , David Malka ...
来源:[J].European Journal of Cancer(IF 5.061), 2005, Vol.42 (4), pp.456-459
摘要:Abstract(#br)This study assessed the clinical activity and safety of irinotecan (CPT-11) in patients with advanced hepatocellular carcinoma (HCC) using dose adjustment according to baseline serum bilirubin level. Patients with advanced HCC received CPT-11 at a dose of 350 mg...
作者:... Jean-Baptiste Bachet , Dewi Vernerey , Mohamed Hebbar
来源:[J].Annals of Surgical Oncology(IF 4.12), 2020, Vol.27 (5), pp.877-885
摘要:Abstract(#br)Background(#br)Despite improvement in colorectal liver metastasis (CLM) treatment, survival after liver surgery remains highly variable. Several clinicopathologic prognostic factors have been reported, but their validity in the era of more effective perioperativ...

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