全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Mitsuhiro Tsuchiya , Kayo Shimada ...
来源:[J].BMC Infectious Diseases(IF 3.025), 2017, Vol.17 (1)Springer
摘要:Twenty-seven clinical isolates of carbapenem-resistant Klebsiella pneumoniae with MICs ≥4 mg/L for imipenem or meropenem were obtained from inpatients in a hospital in Vietnam. Antimicrobial susceptibility tests and whole genome sequencing were performed. Multilocus sequence...
作者:Mitsuhiro Tsuchiya , Brian K Kennedy
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.3 (11)DOAJ
摘要:BACKGROUND: Identification of genes that modulate longevity is a major focus of aging-related research and an area of intense public interest. In addition to facilitating an improved understanding of the basic mechanisms of aging, such genes represent potential targets for therap...
作者:Mitsuhiro Tsuchiya , Delana Miller ...
来源:[J].PLoS Genetics(IF 8.694), 2015, Vol.11 (1)DOAJ
摘要:Elevated proteasome activity extends lifespan in model organisms such as yeast, worms and flies. This pro-longevity effect might be mediated by improved protein homeostasis, as this protease is an integral module of the protein homeostasis network. Proteasomes also regulate cellu...
作者:Mitsuhiro Tsuchiya , Matt Kaeberlein ...
来源:[J].PLoS Genetics(IF 8.694), 2014, Vol.10 (12)DOAJ
摘要:The common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general pro-longevity role for ibuprofen and its mechanistic basis remains unclear. Here we show that ibuprofen increased the lifespan of ...
作者:Mitsuhiro Tsuchiya , Scott Tsuchiyama ...
来源:[J].Cell Metabolism(IF 14.619), 2015, Vol.22 (5), pp.895-906Elsevier
摘要:Summary(#br)Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and M. musculus . We performed a systematic analysis of yeast RLS in a set of 4,698 viable single-gene deletion stra...
作者:Mitsuhiro Tsuchiya , Di Hu ...
来源:[J].Cell(IF 31.957), 2008, Vol.133 (2), pp.292-302Elsevier
摘要:Summary(#br)In nearly every organism studied, reduced caloric intake extends life span. In yeast, span extension from dietary restriction is thought to be mediated by the highly conserved, nutrient-responsive target of rapamycin (TOR), protein kinase A (PKA), and Sch9 kinases. Th...
作者:Mitsuhiro Tsuchiya , Matt Kaeberlein ...
来源:[J].PLOS Genetics(IF 8.694), 2014, Vol.10 (12)PLOS
摘要:The common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general pro-longevity role for ibuprofen and its mechanistic basis remains unclear. Here we show that ibuprofen increased the lifespan of ...
作者:Mitsuhiro Tsuchiya , Delana Miller ...
来源:[J].PLOS Genetics(IF 8.694), 2015, Vol.11 (1)PLOS
摘要:Elevated proteasome activity extends lifespan in model organisms such as yeast, worms and flies. This pro-longevity effect might be mediated by improved protein homeostasis, as this protease is an integral module of the protein homeostasis network. Proteasomes also regulate cellu...
作者:Mitsuhiro Tsuchiya , Nick Dang ...
来源:[J].Aging Cell(IF 5.705), 2006, Vol.5 (6), pp.505-514Wiley
摘要:Summary(#br)Two models have been proposed for how calorie restriction (CR) enhances replicative longevity in yeast: (i) suppression of rDNA recombination through activation of the sirtuin protein deacetylase Sir2 or (ii) decreased activity of the nutrient‐responsive kinases ...

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