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作者:... Bernard Lardy , Françoise Morel , Minh Vu Chuong Nguyen
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2020, Vol.521 (2), pp.383-388
摘要:Abstract(#br)The NADPH oxidase Nox4 is a multi-pass membrane protein responsible for the generation of reactive oxygen species that are implicated in cellular signaling but may also cause pathological situations when dysregulated. Although topological organization of integral mem...
作者:Minh Vu Chuong Nguyen , Athan Baillet ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (7)
摘要:S100A8 and S100A9 are two calcium binding Myeloid Related Proteins, and important mediators of inflammatory diseases. They were recently introduced as partners for phagocyte NADPH oxidase regulation. However, the precise mechanism of their interaction remains elusive. We had for ...
作者:Minh Vu Chuong Nguyen , Laurent Grange ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (6)
摘要:Interleukin-1β (IL-1β) activates the production of reactive oxygen species (ROS) and secretion of MMPs as well as chondrocyte apoptosis. Those events lead to matrix breakdown and are key features of osteoarthritis (OA). We confirmed that in human C-20/A4 chondrocytes the NAD...
作者:Minh Vu Chuong Nguyen , Bernard Lardy ...
来源:[J].Biochemical Pharmacology(IF 4.576), 2013, Vol.85 (11), pp.1644-1654
摘要:Abstract(#br)NADPH oxidase Nox4 is expressed in a wide range of tissues and plays a role in cellular signaling by providing reactive oxygen species (ROS) as intracellular messengers. Nox4 oxidase activity is thought to be constitutive and regulated at the transcriptional lev...
作者:Minh Vu Chuong Nguyen , Leilei Zhang ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2012, Vol.419 (3), pp.453-458
摘要:Abstract(#br)The membrane protein NADPH (nicotinamide adenine dinucleotide phosphate) oxidase Nox4 constitutively generates reactive oxygen species differing from other NADPH oxidases activity, particularly in Nox2 which needs a stimulus to be active. Although the precise me...
作者:Minh Vu Chuong Nguyen , Bernard Lardy ...
来源:[J].Biochimie(IF 3.142), 2011, Vol.93 (3), pp.457-468
摘要:Abstract(#br)Nox4, a member of Nox family of NADPH oxidase expressed in nonphagocytic cells, is a major source of reactive oxygen species in many cell types. But understanding of the role of Nox4 in the production of ROS and of regulation mechanism of oxidase activity is lar...
作者:Minh Vu Chuong Nguyen , Françoise Morel ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2007, Vol.361 (2), pp.493-498
摘要:Abstract(#br)Oxidative stress is a metabolic situation used by immune cells to provide protection against infection. Under activation by threatening elements, phagocytes produce chemically toxic molecules, namely the reactive oxygen species (ROS) and reactive nitrogen species (RN...
作者:Minh Vu Chuong Nguyen , Athan Baillet ...
来源:[J].Joint Bone Spine(IF 2.748), 2018
摘要:Abstract(#br)Objectives(#br)Tumour necrosis factor-alpha inhibitors (TNFi) are effective treatments for Rheumatoid Arthritis (RA). Responses to treatment are barely predictable. As these treatments are costly and may induce a number of side effects, we aimed at identifying a...

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