全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Mikael Bjursell , Xiufeng Xu ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (12)DOAJ
摘要:GPR120 (Ffar4) has been postulated to represent an important receptor mediating the improved metabolic profile seen upon ingestion of a diet enriched in polyunsaturated fatty acids (PUFAs). GPR120 is highly expressed in the digestive system, adipose tissue, lung and macrophages a...
作者:Mikael Bjursell , Marianne Wedin ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (5)DOAJ
摘要:Nuclear receptor subfamily 1, group H, member 4 (Nr1h4, FXR) is a bile acid activated nuclear receptor mainly expressed in the liver, intestine, kidney and adrenal glands. Upon activation, the primary function is to suppress cholesterol 7 alpha-hydroxylase (Cyp7a1), the rate-limi...
作者:Mikael Bjursell , Anna-Karin Sjögren ...
来源:[J].Autoimmunity Reviews(IF 7.975), 2016, Vol.15 (11), pp.1062-1070Elsevier
摘要:Abstract(#br)RORγ is a nuclear hormone receptor which controls polarization of naive CD4 + T-cells into proinflammatory Th17 cells. Pharmacological antagonism of RORγ has therapeutic potential for autoimmune diseases; however, this mechanism may potentially carry target-rela...
作者:Mikael Bjursell , Tomas Drmota ...
来源:[J].Chemistry & Biology(IF 6.157), 2014, Vol.21 (11), pp.1486-1496Elsevier
摘要:Summary(#br)Inhibition of AMP deaminase (AMPD) holds the potential to elevate intracellular adenosine and AMP levels and, therefore, to augment adenosine signaling and activation of AMP-activated protein kinase (AMPK). To test the latter hypothesis, novel AMPD pan inhibitors were...
作者:Mikael Bjursell , Maria Lennerås ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2007, Vol.363 (3), pp.633-638Elsevier
摘要:Abstract(#br)In this study, mice carrying a disrupted gene encoding GPR10 (GPR10 KO) were studied to elucidate the function and importance of this receptor regarding metabolism. Female and male GPR10 KO mice had higher body weight after 11 and 15 weeks of age, respectively. The i...
作者:Mikael Bjursell , Anna-Karin Gerdin ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2006, Vol.348 (2), pp.359-366Elsevier
摘要:Abstract(#br)Obesity has been proposed to be a result of an imbalance in the physiological system that controls and maintains the body energy homeostasis. Several G-protein coupled receptors (GPCRs) are involved in the regulation of energy homeostasis. To investigate the importan...
作者:Mikael Bjursell , Emil Egecioglu ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2004, Vol.326 (4), pp.759-765Elsevier
摘要:Abstract(#br)The hypothalamic peptide melanin-concentrating hormone (MCH) and the gastric hormone ghrelin take part in the regulation of energy homeostasis and stimulate food intake. In the present study, ghrelin was administered centrally to MCH-receptor knockout (MCHr KO) mice....
作者:Mikael Bjursell , Maria Björkman ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2006, Vol.349 (2), pp.825-832Elsevier
摘要:Abstract(#br)Using the mouse as a model organism in pharmaceutical research presents unique advantages as its physiology in many ways resembles the human physiology, it also has a relatively short generation time, low breeding and maintenance costs, and is available in a wid...

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