全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:... Albert Carbonell , Miguel Beato , Fernando Azorín
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.1-8DOAJ
摘要:Abstract Chromatin is known to undergo extensive remodeling during nuclear reprogramming. However, the factors and mechanisms involved in this remodeling are still poorly understood and current experimental approaches to study it are not best suited for molecular and genetic anal...
作者:... Tracy K Hale , Detlef Doenecke , Miguel Beato
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.4 (10)DOAJ
摘要:Although ubiquitously present in chromatin, the function of the linker histone subtypes is partly unknown and contradictory studies on their properties have been published. To explore whether the various H1 subtypes have a differential role in the organization and dynamics of chr...
作者:... Michiel Vermeulen , Matthias Mann , Miguel Beato
来源:[J].PLoS Genetics(IF 8.694), 2009, Vol.5 (7)DOAJ
摘要:Steroid hormones regulate gene expression by interaction of their receptors with hormone responsive elements (HREs) and recruitment of kinases, chromatin remodeling complexes, and coregulators to their target promoters. Here we show that in breast cancer cells the BAF, but not th...
作者:... Erika Diani , Miguel Beato , Albert Jordan
来源:[J].PLoS Genetics(IF 8.517), 2008, Vol.4 (10)DOAJ
摘要:At least six histone H1 variants exist in somatic mammalian cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be actively involved in the regulation of gene expression. However, it i...
作者:... Martin Teichmann , Susana de la Luna , Miguel Beato
来源:[J].Molecular Cell(IF 15.28), 2020, Vol.77 (3), pp.475-487.e11Elsevier
摘要:Summary(#br)How repetitive elements, epigenetic modifications, and architectural proteins interact ensuring proper genome expression remains poorly understood. Here, we report regulatory mechanisms unveiling a central role of Alu elements (AEs) and RNA polymerase III transcriptio...
作者:Miguel Beato , Reyes Candau ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 1996, Vol.56 (1), pp.47-59Elsevier
摘要:Abstract(#br)The mechanism by which steroid hormones modulate promoter utilization is not clear. Evidence from transfection studies and cell-free assays points to an interaction of the hormone receptors with general transcription factors, as well as with sequence-specific transcr...
作者:... Guillermo P. Vicent , Patricia Saragüeta , Miguel Beato
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2006, Vol.102 (1), pp.2-10Elsevier
摘要:Abstract(#br)In addition to transcriptional effects, steroid hormones rapidly activate cytoplasmic signaling cascades. The ultimate targets of these cascades are not well-defined and likely include transcription factors and coactivators. To better understand the role of the ...
作者:... Esteban Hoijman , Miguel Beato , Adali Pecci
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2008, Vol.109 (3), pp.273-278Elsevier
摘要:Abstract(#br)Physiological cell turnover is under the control of a sharp and dynamic balance of different homeostatic mechanisms such as the equilibrium between cell proliferation and cell death. These mechanisms play an important role in maintaining normal tissue function and ar...
作者:Reyes Candau , Sebastián Chávez , Miguel Beato
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 1996, Vol.57 (1), pp.19-31Elsevier
摘要:Abstract(#br)The mouse mammary tumor virus (MMTV) promoter is transcriptionally silent prior to hormonal induction, partly because its organization into phased nucleosomes precludes access of transcription factors to their cognate sites. A T47D-derived cell line carrying a single...
作者:Guillermo P Vicent , Ronald Koop , Miguel Beato
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2002, Vol.83 (1), pp.15-23Elsevier
摘要:Abstract(#br)Transcription from the mouse mammary tumor virus (MMTV) promoter can be induced by glucocorticoids or progestins. The corresponding receptors bind to a cluster of hormone responsive elements (HREs) and activate the promoter by synergistic interactions with ubiquitous...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×