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作者:... Paul M. Thompson , Michel Bottlaender , Marie Sarazin
来源:[J].Neurobiology of Aging(IF 6.166), 2019, Vol.84, pp.41-49
摘要:Abstract(#br)Measuring the morphology of brain sulci has been recently proposed as a novel imaging approach in Alzheimer's disease (AD). We aimed to investigate the relevance of such an approach in AD, by exploring its (1) clinical relevance in comparison with traditional imaging...
作者:Michel Bottlaender , David Brooks ...
来源:[J].Alzheimer's & Dementia: The Journal of the Alzheimer's Association(IF 14.483), 2019, Vol.15 (8), pp.1081-1103
摘要:Abstract(#br)Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for th...
作者:Michel Bottlaender , Helene Corne ...
来源:[J].Neurobiology of Aging(IF 6.166), 2015, Vol.36 (11), pp.2932-2939
摘要:Abstract(#br)We investigated the utility of sulcal width measures in the diagnosis of Alzheimer's disease (AD). Sixty-six biologically confirmed AD patients (positive amyloid positron emission tomography [PET] and/or AD cerebrospinal fluid profile) were contrasted to 35 controls ...
作者:Michel Bottlaender , Lorenz Schmid ...
来源:[J].European Journal of Pharmacology(IF 2.592), 1997, Vol.321 (1), pp.13-17
摘要:Abstract(#br)The influence of decreased endogenous γ-aminobutyric acid (GABA) concentration on benzodiazepine receptor function was studied in the brain of living baboons. Positron emission tomography and the radiotracer [ 11 C]flumazenil combined with electroencephalography...
作者:Michel Bottlaender , Carl-Gunnar Swahn ...
来源:[J].Nuclear Medicine and Biology(IF 2.517), 1996, Vol.23 (6), pp.813-819
摘要:Abstract(#br)Both FLB 457 and FLB 463, two substituted benzamides with high affinity for the dopamine D-2 receptors, were labeled with bromine-76 for PET investigations. [ 76 Br]FLB 457 was prepared by electrophilic substitution of the tributyltin precursor. The radiochemica...
作者:... Delphine S. Courvoisier , Renaud Maroy , Michel Bottlaender
来源:[J].NeuroImage(IF 6.252), 2013, Vol.79, pp.42-51
摘要:Abstract(#br)The nicotinic system plays an important role in ordinary cognition, particularly in attention. The main nicotinic receptor in the human brain is the heteromeric α4β2 neuronal nicotinic acetylcholine receptor (nAChR), which is distributed throughout the brain, wi...

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