全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Sean Porazinski , Ian Wilson , Michael Ladomery
来源:[J].Gene(IF 2.196), 2018, Vol.670, pp.46-54Elsevier
摘要:Abstract(#br)Alternative splicing is a key process required for the regulation of gene expression in normal development and physiology. It is regulated by splice factors whose activities are in turn regulated by splice factor kinases and phosphatases. The CDC-like protein kinases...
作者:Michael Ladomery , Claudio Vernieri ...
来源:[J].Cellular Oncology(IF 2.4), 2019, Vol.42 (6), pp.815-828Springer
摘要:Abstract(#br) Purpose(#br)Isothiocyanates elicit anticancer effects by targeting cancer stem cells (CSCs). Here, we tested the antitumor activity of phenethyl-isothiocyanate (PEITC), either alone or in combination with trastuzumab, in HER2-positive tumor models.(#br) Methods(#br)...
作者:Michael Ladomery , John Sommerville
来源:[J].BBA - Gene Regulatory Mechanisms(IF 5.456), 2015, Vol.1849 (11), pp.1363-1373Elsevier
摘要:Abstract(#br)Oocytes accumulate mRNAs in the form of maternal ribonucleoprotein (RNP) particles, the protein components of which determine the location and stability of individual mRNAs prior to translation. Scd6/Lsm14 proteins, typified by RAP55, function in a wide range of euka...
作者:Sean Porazinski , Michael Ladomery
来源:[J].Genes, 2018, Vol.9 (3)DOAJ
摘要:Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and of...
作者:Michael Ladomery , Elda Tagliabue
来源:[J].Cancers, 2019, Vol.11 (7)DOAJ
摘要:Human epidermal growth factor receptor 2 ( ERBB2 or HER2) amplification/overexpression is associated with a particularly aggressive molecular subtype of breast cancer (BC), characterized by a poor prognosis, increased metastatic potential, and disease recurrence. As only app...
作者:... John Hancock , Ian Wilson , Michael Ladomery
来源:[J].2018, Vol.18 (1), pp.355BMC
摘要:Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of cancer associated genes using the prostate cancer cell line PC3 as a...
作者:Michael Ladomery , Scott Lyons , John Sommerville
来源:[J].Gene(IF 2.196), 1997, Vol.198 (1), pp.275-280Elsevier
摘要:Abstract(#br)Modification of core histones can alter chromatin structure, facilitating the activation and repression of genes. A key example is the acetylation of N-terminal lysines of the core histones. Recently, the mammalian histone deacetylase HD1 was cloned from Jurkat T cel...
作者:Michael Ladomery , Rachel Marshall ...
来源:[J].Gene(IF 2.196), 2000, Vol.256 (1), pp.293-302Elsevier
摘要:Abstract(#br)The protein C4SR contains two cysteine 4 (C 4 ) zinc-finger motifs at its amino terminus, a stretch of acidic residues in the middle and a series of serine–arginine (SR) repeats at its carboxyl terminus. A cDNA clone encoding the zinc-finger domain was first sel...

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