全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Ruili Huang , Menghang Xia , Richard Beger
来源:[J].Archives of Toxicology(IF 5.215), 2017, Vol.91 (12), pp.3885-3895Springer
摘要:Recent reports have noted that a number of compounds that block the human Ether-à-go-go related gene (hERG) ion channel also induce phospholipidosis (PLD). To explore a hypothesis explaining why most PLD inducers are also hERG inhibitors, a modeling approach was undertaken w...
作者:... Christopher P Austin , Menghang Xia , David M Loeb
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (11)DOAJ
摘要:Chordoma is a rare primary bone malignancy that arises in the skull base, spine and sacrum and originates from remnants of the notochord. These tumors are typically resistant to conventional chemotherapy, and to date there are no FDA-approved agents to treat chordoma. The la...
作者:Menghang Xia , Christopher P. Austin
来源:[J].The AAPS Journal(IF 4.386), 2012, Vol.14 (3), pp.473-480Springer
摘要:Abstract(#br)The limitations of traditional toxicity testing characterized by high-cost animal models with low-throughput readouts, inconsistent responses, ethical issues, and extrapolability to humans call for alternative strategies for chemical risk assessment. A new strat...
作者:... Raymond R. Tice , Christopher P. Austin , Menghang Xia
来源:[J].Chem. Res. Toxicol., 2013, Vol.26 (9), pp.1323鈥?332ACS
摘要:‡ Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, United States ... Here, we evaluated the effect of chemical compounds on mitochondrial membrane potential in HepG2 cells by scree...
作者:Menghang Xia , Lena Smirnova ...
来源:[J].Journal of Applied Toxicology(IF 2.597), 2017, Vol.37 (2), pp.167-180Wiley
摘要:Abstract(#br)More than 75 000 man‐made chemicals contaminate the environment; many of these have not been tested for toxicities. These chemicals demand quantitative high‐throughput screening assays to assess them for causative roles in neurotoxicities, including Parkinson's ...
作者:... Bin Zhao , Michael F. Santillo , Menghang Xia
来源:[J].Biotechnology Journal(IF 3.446), 2017, Vol.12 (5), pp.n/a-n/aWiley
摘要:Abstract(#br)Acetylcholinesterase (AChE) is an enzyme responsible for metabolism of acetylcholine, a neurotransmitter associated with muscle movement, cognition, and other neurobiological processes. Inhibition of AChE activity can serve as a therapeutic mechanism, but also c...

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