全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Melih Acar , Hamed Jafar-Nejad ...
来源:[J].Cell(IF 31.957), 2007, Vol.132 (2), pp.247-258Elsevier
摘要:Summary(#br)Notch signaling is broadly used to regulate cell-fate decisions. We have identified a gene, rumi, with a temperature-sensitive Notch phenotype. At 28°C–30°C, rumi clones exhibit a full-blown loss of Notch signaling in all tissues tested. However, at 18°C onl...
作者:Melih Acar , Vafa Bayat ...
来源:[J].Developmental Cell(IF 12.861), 2005, Vol.9 (3), pp.351-363Elsevier
摘要:Summary(#br)Asymmetric division of sensory organ precursors (SOPs) in Drosophila generates different cell types of the mature sensory organ. In a genetic screen designed to identify novel players in this process, we have isolated a mutation in Drosophila sec15 , which encode...
作者:Melih Acar , Glenn L. Radice
来源:[J].Cell Stem Cell(IF 25.315), 2008, Vol.4 (2), pp.170-179Elsevier
摘要:Summary(#br)According to the “osteoblastic niche” model, hematopoietic stem cells (HSCs) are maintained by N-cadherin-mediated homophilic adhesion to osteoblasts at the bone marrow endosteum. In contrast to this model, we cannot detect N-cadherin expression by HSCs, and most...
作者:Melih Acar , Chunyao Tao
来源:[J].Current Biology(IF 9.494), 2006, Vol.16 (22), pp.2228-2233Elsevier
摘要:Summary(#br)The Notch signaling pathway plays a central role in animal growth and patterning, and its deregulation leads to many human diseases, including cancer [1, 2]. Mutations in the tumor suppressor lethal giant discs ( lgd ) induce strong Notch activation and hyperplas...
作者:Melih Acar , Hamed Jafar Nejad ...
来源:[J].Developmental Biology(IF 3.868), 2007, Vol.306 (1), pp.301-301Elsevier
作者:Melih Acar , Zeping Hu ...
来源:[J].Cancer & Metabolism, 2015, Vol.3 (1)Springer
摘要:Abstract(#br) Background(#br)Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose to an aerobic fate rather than an anaerobic one. Rapidly proliferating tissues, including h...

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