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作者:Megumi Tagami , Shinya Kasai ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.4 (9)
摘要:Opioids are commonly used as effective analgesics for the treatment of acute and chronic pain. However, considerable individual differences have been widely observed in sensitivity to opioid analgesics. We focused on a G-protein-activated inwardly rectifying potassium (GIRK) chan...
作者:Megumi Tagami , Masakazu Hayashida ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2015, Vol.127 (3), pp.391-393
摘要:Abstract(#br)An association between postoperative analgesic requirements in subjects who underwent orthognathic surgery and the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 ( TRPC3 ) gene was suggested by our previous gen...
作者:Megumi Tagami , Makoto Nagashima ...
来源:[J].Neuroscience Letters(IF 2.026), 2010, Vol.479 (1), pp.40-43
摘要:Abstract(#br)Although the serotonin (5-hydroxytryptamine (5-HT)) 2A receptor has been reported to be associated with pain, no relationship has been found between single nucleotide polymorphisms in the 5-HT2A receptor gene and analgesic requirements. To clarify the mechanism of in...
作者:Megumi Tagami , Hiroshi Komatsu ...
来源:[J].Pain(IF 5.644), 2009, Vol.147 (1-3), pp.194-201
摘要:Abstract(#br)Individual differences in sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. Still controversial is whether the single nucleotide polymorphisms (SNPs) of the human OPRM1 gene encoding the μ-opioid receptor influence the...
作者:Megumi Tagami , Yasuo Ide ...
来源:[J].Journal of Anesthesia(IF 0.867), 1994, Vol.8 (3), pp.321-325
摘要:Abstract(#br)The effect of intravenously administered pentobarbital sodium on the activity of single unit in Rexed lamina V of the transected feline lumbar spinal cord was studied using an extracellular microelectrode recording technique. Pentobarbital sodium 1.0 mg·kg −1 , ...
作者:Megumi Tagami , Yasuo Ide ...
来源:[J].Journal of Anesthesia(IF 0.867), 2002, Vol.16 (3), pp.211-215
摘要:Abstract(#br) Purpose . The purpose of this study was to assess the effect of local spinal cord cooling on spinal dorsal-horn neuronal activity, with special emphasis on the role of endogenous opioid.(#br) Methods. Decerebrate, spinal-cord-transected cats ( n = 30) were subj...
作者:Megumi Tagami , Hiroshi Ujike ...
来源:[J].Molecular Brain(IF 4.202), 2015, Vol.8 (1)
摘要:Abstract(#br) Background(#br)Many genetic and environmental factors are involved in the etiology of nicotine dependence. Although several candidate gene variations have been reported by candidate gene studies or genome-wide association studies (GWASs) to be associated with s...
作者:Megumi Tagami , Shinya Kasai
来源:[J].Current Pain and Headache Reports(IF 1.672), 2007, Vol.11 (2), pp.115-123
摘要:Abstract(#br)Opiate analgesics have been widely used for severe acute pain and chronic cancer-related pain. Individual differences in the effectiveness of opiates and their side effects limit the clinical benefits and increase risks of drug abuse. Genetic factors might affect var...
作者:Megumi Tagami , Yasuo Ide ...
来源:[J].Anesthesia & Analgesia(IF 3.3), 1995, Vol.80 (1), pp.58-63
摘要:The effects of intravenously (IV) administered midazolam on noxiously evoked activity of spinal wide dynamic range (WDR) neurons were investigated in decerebrate, spinal-cord-transected cats. Extracellular, single-unit recordings were measured during stimulation by pinching the r...
作者:Megumi Tagami , Shinya Kasai ...
来源:[J].PLOS ONE(IF 3.73), 2009, Vol.4 (9)
摘要:Opioids are commonly used as effective analgesics for the treatment of acute and chronic pain. However, considerable individual differences have been widely observed in sensitivity to opioid analgesics. We focused on a G-protein-activated inwardly rectifying potassium (GIRK)...

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