全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Matthew Brecher , Hui Chen ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (6)DOAJ
摘要:The flavivirus methyltransferase (MTase) is an essential enzyme that sequentially methylates the N7 and 2'-O positions of the viral RNA cap, using S-adenosyl-L-methionine (SAM) as a methyl donor. We report here that small molecule compounds, which putatively bind to the SAM-bindi...
作者:Dilip K. Nag , Matthew Brecher , Laura D. Kramer
来源:[J].Virology(IF 3.367), 2016, Vol.498, pp.164-171Elsevier
摘要:Abstract(#br)Although infections of vertebrate hosts by arthropod-borne viruses may lead to pathogenic outcomes, infections of vector mosquitoes result in persistent infections, where the virus replicates in the host without causing apparent pathological effects. It is unclear ho...
作者:Matthew Brecher , Zhong Li ...
来源:[J].PLOS Pathogens(IF 9.127), 2017, Vol.13 (5)PLOS
摘要:The flavivirus genome encodes a single polyprotein precursor requiring multiple cleavages by host and viral proteases in order to produce the individual proteins that constitute an infectious virion. Previous studies have revealed that the NS2B cofactor of the viral NS2B-NS3...
作者:Matthew Brecher , Laura Kramer
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (9)PLOS
摘要:Dengue virus (DENV), an arthropod-borne (“arbovirus”) virus, causes a range of human maladies ranging from self-limiting dengue fever to the life-threatening dengue shock syndrome and proliferates well in two different taxa of the Animal Kingdom, mosquitoes and primates. Mos...
作者:Matthew Brecher , Hui Chen ...
来源:[J].PLOS ONE(IF 3.73), 2015, Vol.10 (6)PLOS
摘要:The flavivirus methyltransferase (MTase) is an essential enzyme that sequentially methylates the N7 and 2’-O positions of the viral RNA cap, using S -adenosyl-L-methionine (SAM) as a methyl donor. We report here that small molecule compounds, which putatively bind to the SAM...
作者:Matthew Brecher , Jing Zhang , Hongmin Li
来源:[J].中国病毒学(英文版), 2013, (06), pp.326-336CNKI
摘要:Many flaviviruses are significant human pathogens causing considerable disease burdens, including encephalitis and hemorrhagic fever, in the regions in which they are endemic. A paucity of treatments for flaviviral infections has driven interest in drug development targeting prot...
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作者:Matthew Brecher , Jing Zhang , Hongmin Li
来源:[J].Virologica Sinica, 2013, Vol.28 (6), pp.326-336Springer
摘要:Abstract(#br)Many flaviviruses are significant human pathogens causing considerable disease burdens, including encephalitis and hemorrhagic fever, in the regions in which they are endemic. A paucity of treatments for flaviviral infections has driven interest in drug development t...
作者:Matthew Brecher , Jing Zhang ...
来源:[J].Journal of Biological Chemistry(IF 4.651), 2015, Vol.290 (25), pp.15746-15757Duke University Press
摘要:Interchanging Leu-119 for Pro-119 at the tip of the β4-β5 loop in the first FK506 binding domain (FK1) of the FKBP51 and FKBP52 proteins, respectively, has been reported to largely reverse the inhibitory (FKBP51) or stimulatory (FKBP52) effects of these co-chaperones on the ...

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