全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Massimo Mangino , Karsten Suhre
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)Springer
摘要:Family-based designs, from twin studies to isolated populations with their complex genealogical data, are a valuable resource for genetic studies of heritable molecular biomarkers. Existing software for family-based studies have mainly focused on facilitating association between ...
作者:Massimo Mangino , Tim D. Spector ...
来源:[J].European Radiology(IF 3.548), 2017, Vol.27 (11), pp.4612-4618Springer
摘要:The aim of this study was to investigate the impact of BMI on late gadolinium enhancement (LGE) of the coronary artery wall in identical monozygous twins discordant for BMI. Coronary LGE represents a useful parameter for the detection and quantification of atherosclerotic coronar...
作者:Massimo Mangino , Swee-Lay Thein ...
来源:[J].PLoS ONE(IF 3.73), 2018, Vol.8 (7)DOAJ
摘要:The red blood cell related traits are highly heritable but their genetics are poorly defined. Only 5-10% of the total observed variance is explained by the genetic loci found to date, suggesting that additional loci should be searched using approaches alternative to large meta an...
作者:Massimo Mangino , Agu Tamm ...
来源:[J].PLoS ONE(IF 3.73), 2018, Vol.6 (8)DOAJ
摘要:Osteoarthritis (OA) is the most common form of arthritis and a major cause of disability. This study evaluates the association in Caucasian populations of two single nucleotide polymorphisms (SNPs) mapping to the Human Leukocyte Antigen (HLA) region and deriving from a genome wid...
作者:Massimo Mangino , Raj Gill ...
来源:[J].PLoS Genetics(IF 8.694), 2014, Vol.10 (3)DOAJ
摘要:Nonallelic homologous recombination (NAHR) between highly similar duplicated sequences generates chromosomal deletions, duplications and inversions, which can cause diverse genetic disorders. Little is known about interindividual variation in NAHR rates and the factors that ...
作者:Massimo Mangino , Abraham Aviv ...
来源:[J].Nucleic Acids Research(IF 8.278), 2014, Vol.42 (9), pp.e75-e75Oxford U Press
摘要:Telomeres play a key role in replicative ageing and undergo age-dependent attrition in vivo . Here, we report a novel method, TelSeq, to measure average telomere length from whole genome or exome shotgun sequence data. In 260 leukocyte samples, we show that TelSeq results correla...
作者:Massimo Mangino , Coleen M Damcott ...
来源:[J].PLoS ONE(IF 3.73), 2010, Vol.5 (9)DOAJ
摘要:Telomeres shorten as cells divide. This shortening is compensated by the enzyme telomerase. We evaluated the effect of common variants in the telomerase RNA component (TERC) gene on telomere length (TL) in the population-based Health Aging and Body Composition (Health ABC) S...
作者:Massimo Mangino , Barbara Thorand ...
来源:[J].PLoS Genetics(IF 8.517), 2010, Vol.6 (11)DOAJ
摘要:Elevated levels of acute-phase serum amyloid A (A-SAA) cause amyloidosis and are a risk factor for atherosclerosis and its clinical complications, type 2 diabetes, as well as various malignancies. To investigate the genetic basis of A-SAA levels, we conducted the first genom...

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