全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Masayuki Takahashi , Noriyuki Tsujimura ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (12)DOAJ
摘要:Despite recent advancements, it is still difficult to evaluate in vivo responses to toxicants in humans. Development of a system that can mimic the in vivo responses of human cells will enable more accurate health risk assessments. A surrogate human hematopoietic lineage can...
作者:Masayuki Takahashi , Reyad A Elbarbary ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (6)DOAJ
摘要:tRNase Z(L)-utilizing efficacious gene silencing (TRUE gene silencing) is a newly developed technology to suppress mammalian gene expression. TRUE gene silencing works on the basis of a unique enzymatic property of mammalian tRNase Z(L), which is that it can recognize a pre-tRNA-...
作者:Masayuki Takahashi , Chantal Prevost
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (11)DOAJ
摘要:We previously reported that a 24 amino acid peptide (NFL-TBS.40-63) corresponding to the tubulin-binding site located on the light neurofilament subunit, selectively enters in glioblastoma cells where it disrupts their microtubule network and inhibits their proliferation. He...
作者:Masayuki Takahashi , Masato Tamura ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (3)DOAJ
摘要:Several pieces of evidence suggest that small RNA degradation products together with tRNase ZL appear to form another layer of the whole gene regulatory network. The degraded RNA such as a 5'-half-tRNA and an rRNA fragment function as small guide RNA (sgRNA) to guide the enzyme t...
作者:Masayuki Takahashi , Hiroshi Nishida
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.4 (6)DOAJ
摘要:A long form (tRNase Z(L)) of tRNA 3' processing endoribonuclease (tRNase Z, or 3' tRNase) can cleave any target RNA at any desired site under the direction of artificial small guide RNA (sgRNA) that mimics a 5'-half portion of tRNA. Based on this enzymatic property, a gene silenc...
作者:... Kentaro Takano , Masayuki Takahashi , Mikio Yamasaki
来源:[J].Acta Crystallographica Section E(IF 0.347), 2010, Vol.66 (8), pp.o1892DOAJ
摘要:The molecule of the title compound, C16H11N3O3, exists in the keto form and the C=O and N—H bonds are mutually cis in the crystal structure. There are two crystallographically independent molecules per asymmetric unit with broadly similar structural data. The only noticeable...
作者:Masayuki Takahashi , Takaaki Fukushima
来源:[J].Acta Crystallographica Section E(IF 0.347), 2009, Vol.65 (12), pp.o3127DOAJ
摘要:The molecule of the title compound, C21H16N2O, exists in the keto form and the C=O and N—H bonds are mutually cis in the crystal structure, although an enol form would be possible through tautomerism. The dihedral angle between the quinoline and the naphthalene systems is 22...
作者:Masayuki Takahashi , Atsushi Maekawa
来源:[J].Acta Crystallographica Section E(IF 0.347), 2010, Vol.66 (2), pp.o429DOAJ
摘要:The main molecule of the title methanol solvate, C16H10Cl2N2O·CH3OH, exists in the keto form and the C=O and N—H bonds are mutually cis in the crystal structure. The dihedral angle between the quinoline and benzene rings is 11.17 (3)°. A bifurcated intramolecular N—H......

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