全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Masayoshi Mishina , Kenji Hashimoto
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2017, Vol.135 (3), pp.138-140Elsevier
摘要:Abstract(#br)We investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N -methyl- d -aspartate (NMDA) receptor GluN2D subunit knockout (GluN2D-KO) mice. Intraperitoneal administration of ketamine or its enantiomers 10 min before the tail-suspens...
作者:... Masahiko Watanabe , Toshiya Manabe , Masayoshi Mishina
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.4 (1)DOAJ
摘要:Synchronized discharges in the hippocampal CA3 recurrent network are supposed to underlie network oscillations, memory formation and seizure generation. In the hippocampal CA3 network, NMDA receptors are abundant at the recurrent synapses but scarce at the mossy fiber synapses. W...
作者:... Shigeyoshi Itohara , Kenji Sakimura , Masayoshi Mishina
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.4 (1)DOAJ
摘要:Fear is one of the most potent emotional experiences and is an adaptive component of response to potentially threatening stimuli. On the other hand, too much or inappropriate fear accounts for many common psychiatric problems. Cumulative evidence suggests that the amygdala plays ...
作者:Masayoshi Mishina , Kenji Hashimoto
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2017, Vol.135 (3), pp.138-140DOAJ
摘要:We investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N-methyl-d-aspartate (NMDA) receptor GluN2D subunit knockout (GluN2D-KO) mice. Intraperitoneal administration of ketamine or its enantiomers 10 min before the tail-suspension test exerted...
作者:... Toshifumi Yamamoto , Masayoshi Mishina , Kazutaka Ikeda
来源:[J].Neuropharmacology(IF 4.114), 2017, Vol.112, pp.188-197Elsevier
摘要:Abstract(#br)The N -methyl- d -aspartate (NMDA) receptor channel is involved in various physiological functions, including learning and memory. The GluN2D subunit of the NMDA receptor has low expression in the mature brain, and its role is not fully understood. In the presen...
作者:Masayoshi Mishina , Thomas L. Kash
来源:[J].Behavioural Brain Research(IF 3.327), 2018Elsevier
摘要:Abstract(#br)The N -methyl- D -aspartate receptor (NMDAR) is mechanistically involved in the behavioral and neurophysiological effects of alcohol, but the specific role of the GluN2A subunit remains unclear. Here, we exposed mice with constitutive GluN2A gene knockout (KO) to chr...
作者:Masayoshi Mishina , Kiyofumi Yamada ...
来源:[J].Neuropharmacology(IF 4.114), 2019, Vol.148, pp.107-116Elsevier
摘要:Abstract(#br)The impairment of social behaviors induced by social defeat stress exposure as juveniles is resistant to some antidepressants and an antipsychotic, although the underlying mechanisms and/or therapeutic target are not yet clear. In this study, we investigated the...
作者:... Kenji Sakimura , Masayoshi Mishina , Takao Shimizu
来源:[J].Cell Metabolism(IF 14.619), 2014, Vol.20 (2), pp.295-305Elsevier
摘要:Summary(#br)The acyl-chain composition of the major mammalian phospholipid phosphatidylcholine (PC) is distinct in various tissues. Although it was classically suggested that PC diversity is acquired through acyl-chain remodeling, the mechanisms and biological relevance of acyl-c...
作者:Masayoshi Mishina , Rolf Sprengel ...
来源:[J].Behavioural Brain Research(IF 3.327), 2015, Vol.287, pp.89-95Elsevier
摘要:Abstract(#br)Drugs targeting the glutamate N -methyl- d -aspartate receptor (NMDAR) may be efficacious for treating mood disorders, as exemplified by the rapid antidepressant effects produced by single administration of the NMDAR antagonist ketamine. Though the precise mechanisms...

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