全部文献期刊会议图书|学者科研项目
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作者:Mark S. Filla , Kaylee D. Dimeo ...
来源:[J].Experimental Eye Research(IF 3.026), 2017
摘要:Abstract(#br)Fibronectin fibrils are a major component of the extracellular matrix (ECM) of the trabecular meshwork (TM). They are a key mediator of the formation of the ECM which controls aqueous humor outflow and contributes to the pathogenesis of glaucoma. The purpose of this ...
作者:Mark S. Filla , Jennifer A. Faralli ...
来源:[J].Experimental Eye Research(IF 3.026), 2016, Vol.158
摘要:Abstract(#br)Integrins are a family of heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix (ECM). In addition to their role as adhesion receptors, integrins can act as ‘‘bidirectional signal transducers’’ that coordinate a large numbe...
作者:... Ross W. Clark , Mark S. Filla , Donna M. Peters
来源:[J].Experimental Eye Research(IF 3.026), 2015, Vol.130, pp.9-16
摘要:Abstract(#br)Mutations in the myocilin gene ( MYOC ) account for 10% of juvenile open-angle glaucoma cases and 3–4% of adult onset primary open-angle glaucoma cases. It is a secreted glycoprotein found in many ocular and non-ocular tissues and has been linked to elevated int...
作者:Mark S. Filla , Ross Clark , Donna M. Peters
来源:[J].Experimental Cell Research(IF 3.557), 2014, Vol.327 (2), pp.171-182
摘要:Abstract(#br)In this study, we examined the role(s) of syndecan-4 in regulating the formation of an actin geodesic dome structure called a cross-linked actin network (CLAN) in which syndecan-4 has previously been localized. CLANs have been described in several different cell...
作者:Mark S. Filla , Heather M. Stanley ...
来源:[J].Developmental Biology(IF 3.868), 2001, Vol.239 (1), pp.79-94
摘要:Abstract(#br)Myogenesis in the embryo and the adult mammal consists of a highly organized and regulated sequence of cellular processes to form or repair muscle tissue that include cell proliferation, migration, and differentiation. Data from cell culture and in vivo experime...
作者:... Jose M. Gonzalez , Mark S. Filla , Donna M. Peters
来源:[J].Experimental Eye Research(IF 3.026), 2008, Vol.88 (4), pp.689-693
摘要:Abstract(#br)Fibronectin plays a number of important roles in the extracellular matrix (ECM) including providing structural support and signaling cues for cell survival, migration, differentiation, gene expression, growth factor signaling, and cell contractility. In this review, ...
作者:Mark S. Filla , Tania N. Crotti
来源:[J].BBA - Molecular Cell Research(IF 4.808), 2013, Vol.1833 (12), pp.3306-3313
摘要:Abstract(#br)The purpose of this study was to determine how dexamethasone (DEX) regulates the expression and activity of αvβ3 integrin. FACS analysis showed that DEX treatment induced expression of an activated αvβ3 integrin. Its expression remained high as long as DEX was p...
作者:Mark S. Filla , Sarah R. Slauson ...
来源:[J].Current Eye Research(IF 1.71), 2014, Vol.39 (9), pp.859-870
摘要:Abstract Currently, the most effective outflow drugs approved for clinical use are prostaglandin F2α analogues, but these require daily topical self-dosing and have various intraocular, ocular surface and extraocular side effects. Lentiviral vector-mediated delivery of the ...
作者:Mark S. Filla , Phoungan Dam , Alan C. Rapraeger
来源:[J].Journal of Cellular Physiology(IF 4.218), 1998, Vol.174 (3), pp.310-321
摘要:Abstract(#br)Binding of fibroblast growth factors (FGFs) to receptor tyrosine kinases (FGFRs) and signaling is facilitated by binding of FGF to heparan sulfate proteoglycans (HSPGs). There are multiple families of HSPGs, including extracellular and cell surface forms. An imp...
作者:Benjamin L. Allen , Mark S. Filla , Alan C. Rapraeger
来源:[J].The Journal of Cell Biology(IF 10.822), 2001, Vol.155 (5), pp.845-857
摘要:FGF signaling uses receptor tyrosine kinases that form high-affinity complexes with FGFs and heparan sulfate (HS) proteoglycans at the cell surface. It is hypothesized that assembly of these complexes requires simultaneous recognition of distinct sulfation patterns within the HS ...

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