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作者:... Erik G. Hedlund , Sviatlana Shashkova , Mark C. Leake
来源:[J].Methods(IF 3.641), 2020, Vol.170, pp.82-89
摘要:Abstract(#br)How genomic DNA is organized in the nucleus is a long-standing question. We describe a single-molecule bioimaging method utilizing super-localization precision coupled to fully quantitative image analysis tools, towards determining snapshots of parts of the 3D genome...
作者:Mark C. Leake , Chien-Jung Lo
来源:[J].Molecular Cell(IF 15.28), 2019, Vol.73 (1), pp.143-156.e4
摘要:Summary(#br)Cell dormancy is a widespread mechanism used by bacteria to evade environmental threats, including antibiotics. Here we monitored bacterial antibiotic tolerance and regrowth at the single-cell level and found that each individual survival cell shows different “do...

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