全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Chady H. Hakim , Mark A. McIntosh , Dongsheng Duan
来源:[J].Disease Models & Mechanisms(IF 4.959), 2015, Vol.8 (3), pp.195-213DOAJ
摘要:Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder. It is caused by loss-of-function mutations in the dystrophin gene. Currently, there is no cure. A highly promising therapeutic strategy is to replace or repair the defective dystrophin gene by gene therap...
作者:Mark A. McIntosh , Stefan G. Sarafianos
来源:[J].Antiviral Research(IF 3.925), 2013, Vol.98 (3), pp.380-385Elsevier
摘要:Abstract(#br)Foot-and-mouth disease (FMD) is a highly contagious disease of livestock caused by a highly variable RNA virus (FMDV) that has seven serotypes and more than sixty subtypes. Both prophylactic and post-infection means of controlling the disease outbreak, including...
作者:Jennifer L. Lavrrar , Catherine A. Christoffersen , Mark A. McIntosh
来源:[J].Journal of Molecular Biology(IF 3.905), 2002, Vol.322 (5), pp.983-995Elsevier
摘要:Abstract(#br)The transcriptional repressor Fur binds to a 19-bp consensus sequence, 5′-GATAATGATAATCATTATC-3′, under high iron conditions. The fepDGC-entS promoter of Escherichia coli contains two Fur-binding sites (FBS) offset by 6 bp. Genetic studies of this promoter regio...

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