全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Chady H. Hakim , Mark A. McIntosh , Dongsheng Duan
来源:[J].Disease Models & Mechanisms(IF 4.959), 2015, Vol.8 (3), pp.195-213DOAJ
摘要:Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder. It is caused by loss-of-function mutations in the dystrophin gene. Currently, there is no cure. A highly promising therapeutic strategy is to replace or repair the defective dystrophin gene by gene therap...
作者:Mark A. McIntosh , Stefan G. Sarafianos
来源:[J].Antiviral Research(IF 3.925), 2013, Vol.98 (3), pp.380-385Elsevier
摘要:Abstract(#br)Foot-and-mouth disease (FMD) is a highly contagious disease of livestock caused by a highly variable RNA virus (FMDV) that has seven serotypes and more than sixty subtypes. Both prophylactic and post-infection means of controlling the disease outbreak, including...
作者:Jennifer L. Lavrrar , Catherine A. Christoffersen , Mark A. McIntosh
来源:[J].Journal of Molecular Biology(IF 3.905), 2002, Vol.322 (5), pp.983-995Elsevier
摘要:Abstract(#br)The transcriptional repressor Fur binds to a 19-bp consensus sequence, 5′-GATAATGATAATCATTATC-3′, under high iron conditions. The fepDGC-entS promoter of Escherichia coli contains two Fur-binding sites (FBS) offset by 6 bp. Genetic studies of this promoter regio...
作者:... Glenn E. Morris , Mark A. McIntosh , Dongsheng Duan
来源:[J].PLOS ONE(IF 3.73), 2014, Vol.9 (2)PLOS
摘要:Epitope-specific monoclonal antibodies can provide unique insights for studying cellular proteins. Dystrophin is one of the largest cytoskeleton proteins encoded by 79 exons. The absence of dystrophin results in Duchenne muscular dystrophy (DMD). Over the last two decades, dozens...

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