全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Mario Rottländer , Jan Kehler ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (6)DOAJ
摘要:The voltage-gated potassium channels of the KV7 family (KV7.1-5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability. One of the main challenges in developing KV7 channel active ...
作者:Mario Rottländer , Paul Knochel
来源:[J].Tetrahedron Letters(IF 2.397), 1997, Vol.38 (10), pp.1749-1752Elsevier
摘要:Abstract(#br)The benzylic zinc reagents 3a-c bearing a triflate group in o -, m - or p -position are new efficient multi-coupling reagents reacting stepwise with an aryl iodide (Ar 1 I) and an arylzinc bromide (Ar 2 ZnBr) in the presence of the appropriate palladium catalys...
作者:Mario Rottländer , Charles E. Tucker ...
来源:[J].Tetrahedron(IF 2.803), 1996, Vol.52 (21), pp.7201-7220Elsevier
摘要:Abstract(#br)Functionalized aryl and alkenyl iodides undergo an iodine-lithium exchange at −90 to −80 °C providing polyfunctional organolithiums which are stable for a short time at these low temperatures and can be transmetalated to organozinc derivatives by the additi...
作者:Mario Rottländer , Mingkai Xu ...
来源:[J].Analytical Biochemistry(IF 2.582), 2011, Vol.418 (1), pp.66-72Elsevier
摘要:Abstract(#br)To develop a real-time thallium flux assay for high-throughput screening (HTS) of human KCNQ4 (Kv7.4) potassium channel openers, we used CHO-K1 cells stably expressing human KCNQ4 channel protein and a thallium-sensitive dye based on the permeability of thallium...
作者:Mario Rottländer , Jan Kehler ...
来源:[J].PLOS ONE(IF 3.73), 2014, Vol.9 (6)PLOS
摘要:The voltage-gated potassium channels of the KV7 family (KV7.1–5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability. One of the main challenges in dev...
作者:Mario Rottländer , Gérard Cahiez
来源:[J].Angewandte Chemie International Edition(IF 13.734), 1998, Vol.37 (12), pp.1701-1703Wiley
摘要:Abstract(#br)At −40°C aryl iodides that contain other functional groups can be selectively converted into Grignard reagents, which react with electrophiles such as benzaldehyde in the usual manner [Eq. (a)]. Aryl bromides and iodides that are immobilized as esters on a Wang ...

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