全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Georgios A. Dalkas , Marianne Rooman
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:The identification of immunogenic regions on the surface of antigens, which are able to be recognized by antibodies and to trigger an immune response, is a major challenge for the design of new and effective vaccines. The prediction of such regions through computational immunolog...
作者:Fabrizio Pucci , Marianne Rooman
来源:[J].BMC Genomics(IF 4.397), 2019, Vol.20 (S8), pp.1-11DOAJ
摘要:Abstract Background It is nowadays clear that single base substitutions that occur in the human genome, of which some lead to pathogenic conditions, are non-random and influenced by their flanking nucleobase sequences. However, despite recent progress, the understanding of t...
作者:Marianne Rooman , Jaroslav Albert ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (12)DOAJ
摘要:Available DNA microarray time series that record gene expression along the developmental stages of multicellular eukaryotes, or in unicellular organisms subject to external perturbations such as stress and diauxie, are analyzed. By pairwise comparison of the gene expression profi...
作者:... Jean Marc Kwasigroch , Dimitri Gilis , Marianne Rooman
来源:[J].BMC Bioinformatics(IF 3.024), 2011, Vol.12 (1)Springer
摘要:Abstract(#br) Background(#br)The rational design of modified proteins with controlled stability is of extreme importance in a whole range of applications, notably in the biotechnological and environmental areas, where proteins are used for their catalytic or other functional acti...
作者:Jaroslav Albert , Marianne Rooman
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (11)DOAJ
摘要:Turning genes on and off is a mechanism by which cells and tissues make phenotypic decisions. Gene network motifs capable of supporting two or more steady states and thereby providing cells with a plurality of possible phenotypes are referred to as genetic switches. Modeled on th...
作者:... Malik Dhanani , Yves Dehouck , Marianne Rooman
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (3)DOAJ
摘要:The ability to rationally modify targeted physical and biological features of a protein of interest holds promise in numerous academic and industrial applications and paves the way towards de novo protein design. In particular, bioprocesses that utilize the remarkable proper...
作者:Jaroslav Albert , Marianne Rooman
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (7)DOAJ
摘要:One of the functions of the cell nucleus is to help regulate gene expression by controlling molecular traffic across the nuclear envelope. Here we investigate, via stochastic simulation, what effects, if any, does segregation of a system into the nuclear and cytoplasmic compartme...

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