全部文献期刊会议图书|学者科研项目
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作者:Georgios A. Dalkas , Marianne Rooman
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)
摘要:The identification of immunogenic regions on the surface of antigens, which are able to be recognized by antibodies and to trigger an immune response, is a major challenge for the design of new and effective vaccines. The prediction of such regions through computational immunolog...
作者:Fabrizio Pucci , Marianne Rooman
来源:[J].Current Opinion in Structural Biology(IF 8.738), 2017, Vol.42, pp.117-128
摘要:The molecular bases of thermal and cold stability and adaptation, which allow proteins to remain folded and functional in the temperature ranges in which their host organisms live and grow, are still only partially elucidated. Indeed, both experimental and computational studies f...
作者:Marianne Rooman , Jaroslav Albert ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (12)
摘要:Available DNA microarray time series that record gene expression along the developmental stages of multicellular eukaryotes, or in unicellular organisms subject to external perturbations such as stress and diauxie, are analyzed. By pairwise comparison of the gene expression profi...
作者:Jaroslav Albert , Marianne Rooman
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (11)
摘要:Turning genes on and off is a mechanism by which cells and tissues make phenotypic decisions. Gene network motifs capable of supporting two or more steady states and thereby providing cells with a plurality of possible phenotypes are referred to as genetic switches. Modeled on th...
作者:Fabrizio Pucci , Marianne Rooman
来源:[J].BMC Genomics(IF 4.397), 2019, Vol.20 (S8), pp.1-11
摘要:Abstract Background It is nowadays clear that single base substitutions that occur in the human genome, of which some lead to pathogenic conditions, are non-random and influenced by their flanking nucleobase sequences. However, despite recent progress, the understanding of t...
作者:Marianne Rooman , Yves Moreau
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.1-11
摘要:Abstract Next generation sequencing technologies are providing increasing amounts of sequencing data, paving the way for improvements in clinical genetics and precision medicine. The interpretation of the observed genomic variants in the light of their phenotypic effects is ...
作者:Jaroslav Albert , Marianne Rooman
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (7)
摘要:One of the functions of the cell nucleus is to help regulate gene expression by controlling molecular traffic across the nuclear envelope. Here we investigate, via stochastic simulation, what effects, if any, does segregation of a system into the nuclear and cytoplasmic compartme...
作者:... Malik Dhanani , Yves Dehouck , Marianne Rooman
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (3)
摘要:The ability to rationally modify targeted physical and biological features of a protein of interest holds promise in numerous academic and industrial applications and paves the way towards de novo protein design. In particular, bioprocesses that utilize the remarkable proper...
作者:... Dimitri Gilis , Marianne Rooman , François Chaumont
来源:[J].Molecular Plant(IF 6.126), 2016, Vol.9 (7), pp.986-1003
摘要:Abstract(#br)Aquaporins are channels facilitating the diffusion of water and/or small uncharged solutes across biological membranes. They assemble as homotetramers but some of them also form heterotetramers, especially in plants. In Zea mays , aquaporins belonging to the plasma m...

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