全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Maria Georgiadou , Johanna Ivaska
来源:[J].Trends in Cell Biology(IF 11.721), 2017Elsevier
摘要:Integrin activation is essential for cell adhesion and for connecting the extracellular matrix to the actin cytoskeleton. Thus, inappropriate integrin activation has been linked to several diseases, including cancer. Recent insights demonstrate that the main fibrillar adhesi...
作者:Maria Georgiadou , Jasper Wouters ...
来源:[J].Cancer Cell(IF 24.755), 2014, Vol.26 (2), pp.190-206Elsevier
摘要:Summary(#br)Chloroquine (CQ) has been evaluated as an autophagy blocker for cancer treatment, but it is unknown if it acts solely by inhibiting cancer cell autophagy. We report that CQ reduced tumor growth but improved the tumor milieu. By normalizing tumor vessel structure ...
作者:Maria Georgiadou , Bart Ghesquière ...
来源:[J].Cell Metabolism(IF 14.619), 2014, Vol.19 (1), pp.37-48Elsevier
摘要:Summary(#br)Strategies targeting pathological angiogenesis have focused primarily on blocking vascular endothelial growth factor (VEGF), but resistance and insufficient efficacy limit their success, mandating alternative antiangiogenic strategies. We recently provided genetic evi...
作者:Maria Georgiadou , Konstantina Dimakopoulou ...
来源:[J].Digestive Diseases and Sciences(IF 2.26), 2009, Vol.54 (2), pp.282-291Springer
摘要:Abstract(#br)Minichromosome maintenance (MCM) proteins are essential components of DNA replication, being related to cell proliferation, and serve as useful markers for cancer screening, surveillance, and prognosis. Our aim was to examine the clinical significance of MCM-2 a...
作者:Katrien De Bock , Maria Georgiadou , Peter Carmeliet
来源:[J].Cell Metabolism(IF 14.619), 2013, Vol.18 (5), pp.634-647Elsevier
摘要:Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis. Vascular sprouting relies on the coordinated activity of migrating tip cells at the forefront and proliferating stalk cells that elongate the sprout. Past studies have identified genetic s...
作者:Maria Georgiadou , Sandra Schoors ...
来源:[J].Cell(IF 31.957), 2013, Vol.154 (3), pp.651-663Elsevier
摘要:Summary(#br)Vessel sprouting by migrating tip and proliferating stalk endothelial cells (ECs) is controlled by genetic signals (such as Notch), but it is unknown whether metabolism also regulates this process. Here, we show that ECs relied on glycolysis rather than on oxidative p...
作者:Maria Georgiadou , Pierre Fons ...
来源:[J].Cancer Cell(IF 24.755), 2013, Vol.23 (4), pp.477-488Elsevier
摘要:Summary(#br)Receptor tyrosine kinases (RTK) are targets for anticancer drug development. To date, only RTK inhibitors that block orthosteric binding of ligands and substrates have been developed. Here, we report the pharmacologic characterization of the chemical SSR128129E (SSR),...
作者:Maria Georgiadou , Stefanos Klironomos
来源:[J].European Journal of Clinical Investigation(IF 3.365), 2012, Vol.42 (8), pp.815-822Wiley
摘要:Eur J Clin Invest 2012(#br)Abstract(#br)Background Activin‐A is a molecule of the TGF superfamily, implicated in liver fibrosis, regeneration and stem cell differentiation. However, data on activins in liver diseases are few. We therefore studied serum levels of activin‐A in...
作者:Maria Georgiadou , Guillaume Jacquemet ...
来源:[J].The EMBO Journal(IF 9.822), 2017, Vol.36 (2), pp.165-182Wiley
摘要:Abstract(#br)SHARPIN is a widely expressed multifunctional protein implicated in cancer, inflammation, linear ubiquitination and integrin activity inhibition; however, its contribution to epithelial homeostasis remains poorly understood. Here, we examined the role of SHARPIN...
作者:Maria Georgiadou , Sandra Schoors ...
来源:[J].Cell Cycle(IF 5.243), 2015, Vol.14 (21), pp.3379-3388Taylor & Francis
摘要:Cell division is a metabolically demanding process, requiring the production of large amounts of energy and biomass. Not surprisingly therefore, a cell's decision to initiate division is co-determined by its metabolic status and the availability of nutrients. Emerging evidence re...

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