全部文献期刊会议图书|学者科研项目
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作者:Maria G. Pilo , Antonio Cigliano ...
来源:[J].Journal of Hepatology(IF 9.858), 2017
摘要:Background & Aims(#br)Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. We evaluated the therapeutic potential of MLN0128 vs. gemcitabine/oxal...
作者:Maria G. Pilo , Antonio Cigliano ...
来源:[J].Scientific Reports(IF 2.927), 2016, Vol.6 (1), pp.69-90
摘要:Abstract(#br)Activation of the AKT/mTOR cascade and overexpression of c-Met have been implicated in the development of human hepatocellular carcinoma (HCC). To elucidate the functional crosstalk between the two pathways, we generated a model characterized by the combined expressi...
作者:Maria G. Pilo , Antonio Cigliano ...
来源:[J].Cell Cycle(IF 5.243), 2017, Vol.16 (6), pp.499-507
摘要:ABSTRACT(#br)Hepatocellular carcinoma (HCC), the most frequent primary tumor of the liver, is an aggressive cancer type with limited treatment options. Cumulating evidence underlines a crucial role of aberrant lipid biosynthesis (a process known as de novo lipogenesis) along...
作者:Maria G. Pilo , Antonio Cigliano ...
来源:[J].Hepatology(IF 12.003), 2017, Vol.66 (1), pp.167-181
摘要:Amplification and/or activation of the c‐Myc proto‐oncogene is one of the leading genetic events along hepatocarcinogenesis. The oncogenic potential of c‐Myc has been proven experimentally by the finding that its overexpression in the mouse liver triggers tumor formatio...
作者:Maria G. Pilo , Gianpaolo Vidili ...
来源:[J].Liver International(IF 3.87), 2017, Vol.37 (1), pp.80-89
摘要:Abstract(#br)Background & Aims(#br)Although it is well established that fatty acids ( FA ) are indispensable for the proliferation and survival of cancer cells in hepatocellular carcinoma ( HCC ), inhibition of Fatty Acid Synthase ( FASN ) cannot completely repress HCC cell ...
作者:Maria G. Pilo , Yan Liu ...
来源:[J].Hepatology(IF 12.003), 2015, Vol.61 (1), pp.200-213
摘要:Concomitant expression of activated forms of v‐akt murine thymoma viral oncogene homolog (AKT) and Ras in mouse liver (AKT/Ras) leads to rapid tumor development through strong activation of the mammalian target of rapamycin complex 1 (mTORC1) pathway. mTORC1 functions by reg...
作者:Maria G. Pilo , Silvia Ribback ...
来源:[J].Liver International(IF 3.87), 2016, Vol.36 (8), pp.1176-1186
摘要:Abstract(#br)Background & Aims(#br)Activating mutations of PIK 3 CA occur in various tumour types, including human hepatocellular carcinoma. The mechanisms whereby PIK 3 CA contributes to hepatocarcinogenesis remain poorly understood.(#br)Methods(#br)PIK 3 CA mutants H1047R ...
作者:Maria G. Pilo , Dan Cao ...
来源:[J].Hepatology(IF 12.003), 2016, Vol.63 (6), pp.1900-1913
摘要:Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most prevalent types of primary liver cancer. These malignancies have limited treatment options, resulting in poor patient outcomes. Metabolism reprogramming, including increased de novo lipogen...
作者:Maria G. Pilo , Antonio Cigliano ...
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (9)
摘要:Previous data indicate that Tankyrase inhibitors exert anti-growth functions in many cancer cell lines due to their ability to inactivate the YAP protooncogene. In the present manuscript, we investigated the effect of Tankyrase inhibitors on the growth of hepatocellular carcinoma...

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