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作者:Bellina Veronesi , Marga Oortgiesen
来源:[J].Neurotoxicology(IF 2.652), 2001, Vol.22 (6), pp.795-810Elsevier
摘要:Abstract(#br)Exposure to a class of airborne pollutants known as particulate matter (PM) is an environmental health risk of global proportions. PM is thought to initiate and/or exacerbate respiratory disorders, such as asthma and airway hyper-responsiveness and is epidemiological...
作者:Marga Oortgiesen , Francisco Ramirez
来源:[J].Sleep Medicine(IF 3.487), 2017, Vol.32, pp.48-55Elsevier
摘要:Abstract(#br)Objective(#br)To investigate the pharmacokinetics (PK) of rotigotine transdermal system in adolescents with moderate-to-severe idiopathic restless legs syndrome (RLS).(#br)Methods(#br)This multicenter, open-label, dose-escalation study enrolled patients ≥13 to <...
作者:... Guangwei Wei , Jin-Qi Zeng , Marga Oortgiesen
来源:[J].Neurotoxicology(IF 2.652), 2003, Vol.24 (3), pp.463-473Elsevier
摘要:Abstract(#br)The pathophysiology of neurogenic inflammation culminates in the overt symptoms of tissue inflammation through a series of events which are initiated by the activation of vanilloid receptors (VR1). This study was designed to test the hypothesis that a sufficient...
作者:Marga Oortgiesen , Hanna Pesch
来源:[J].Current Medical Research and Opinion(IF 2.263), 2018, Vol.34 (7), pp.1293-1299Taylor & Francis
摘要:Abstract(#br)Objective:(#br) In patch-based transdermal drug delivery, adhesiveness is critical for safe and effective treatment, especially in Parkinson’s disease (PD) where excessive sweating is common. This study compared the adhesiveness of two transdermal patch formulat...
作者:Marga Oortgiesen , Regina G.D.M van Kleef , Henk P.M Vijverberg
来源:[J].Brain Research(IF 2.879), 1997, Vol.747 (1), pp.1-8Elsevier
摘要:Abstract(#br)In cultured mouse neuroblastoma N1E-115 cells, inorganic lead (Pb 2+ ) affects inward currents induced by activation of neuronal type nicotinic acetylcholine receptors (nAChR) in a biphasic manner. At nanomolar concentrations a blocking action is observed, while...
作者:Marga Oortgiesen , Josee Roy ...
来源:[J].Toxicology and Applied Pharmacology(IF 3.975), 2000, Vol.169 (1), pp.66-76Elsevier
摘要:Abstract(#br)The signs of airway inflammation and hyperresponsiveness that occur in animals exposed to air pollutants are often strain- and species-specific. To investigate the underlying causes of this phenomenon, BALB/c and C57bl/6 mice were exposed intratracheally to resi...
作者:... Regina G.D.M van Kleef , Ruud Zwart , Marga Oortgiesen
来源:[J].Brain Research(IF 2.879), 1998, Vol.789 (2), pp.263-273Elsevier
摘要:Abstract(#br)The effects of acetylcholine (ACh) and physostigmine (PHY) on thoracic ganglion neurons of Locusta migratoria were investigated using whole-cell and cell-attached voltage clamp. ACh activated whole-cell currents with variable amplitudes, time course and ion chan...
作者:... Colin de Haar , Lseng Lee , Marga Oortgiesen
来源:[J].Toxicology and Applied Pharmacology(IF 3.975), 2002, Vol.178 (3), pp.144-154Elsevier
摘要:Abstract(#br)The physicochemical complexity of airborne particulate matter (PM) has hampered identifying a specific mechanism(s) for its toxicity. In this study, selected physicochemical characteristics (i.e., size, particle number, acidity, and surface charge) were measured...
作者:MARGA OORTGIESEN , HELGA H. TIMMERMAN ...
来源:[J].Physiology & Behavior(IF 3.16), 1996, Vol.60 (6), pp.1527-1533Elsevier
摘要:Abstract(#br)Noise is a highly relevant environmental and clinical stressor. Compared to most other experimental stressors, noise is a modest activator of neuroendocrine pathways that mimic the situation in human health where neuroendocrine activation by environmental stress...
作者:Marga Oortgiesen , Erwin Visser ...
来源:[J].Naunyn-Schmiedeberg's Archives of Pharmacology(IF 2.147), 2004, Vol.353 (2), pp.136-143Springer
摘要:Abstract(#br)Effects of organotin compounds were studied on voltage-gated K + current in whole-cell voltage clamped lymphocytes and in NlE-115 neuroblastoma cells. In human peripheral blood lymphocytes the immunotoxic compounds dibutyltinchloride (DBT, 2.5 μM) and triphenylt...

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