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作者:Ana Guzman-Aranguez , María J. Pérez de Lara , Jesús Pintor
来源:[J].Purinergic Signalling(IF 2.635), 2017, Vol.13 (2), pp.249-258
摘要:Tear hyperosmolarity is a key event in dry eye. In this work, we analyzed whether hyperosmolar challenge induces ATP release on the ocular surface. Moreover, as extracellular ATP can activate P2X7 receptor, the changes in P2X7 protein levels and its involvement in pathological pr...
作者:... Alejandro Martínez-Águila , María J. Pérez de Lara , Jesús Pintor
来源:[J].Purinergic Signalling(IF 2.635), 2017, Vol.13 (2), pp.171-177
摘要:Glaucoma is a neurodegenerative disease that produces blindness. The main factor associated with this disease is an abnormally elevated intraocular pressure (IOP). To date, some attempts have been made to demonstrate the role of nucleotides modulating IOP, but never in a mod...
作者:María J. Pérez de Lara , Marcelino Avilés-Trigueros ...
来源:[J].Brain Research Bulletin(IF 2.935), 2019, Vol.150, pp.61-74
摘要:Abstract(#br)Glaucoma is a common cause of visual impairment and blindness, characterized by retinal ganglion cell (RGC) death. The mechanisms that trigger the development of glaucoma remain unknown and have gained significant relevance in the study of this neurodegenerative dise...
作者:María J. Pérez de Lara , Ana Guzmán-Aranguez ...
来源:[J].Purinergic Signalling(IF 2.635), 2018, Vol.14 (3), pp.259-270
摘要:Abstract(#br)The pathogenesis of glaucoma involves numerous intracellular mechanisms including the purinergic system contribution. Furthermore, the presence and release of nucleotides and dinucleotides during the glaucomatous damage and the maintenance of degradation machine...
作者:María J. Pérez de Lara , Concepción Santano ...
来源:[J].Experimental Eye Research(IF 3.026), 2014, Vol.122, pp.40-49
摘要:Abstract(#br)The DBA/2J mouse is a model of ocular hypertension and retinal ganglion cell (RGC) degeneration, the main features of which are iris pigment dispersion (IPD) and iris stromal atrophy (ISA). These animals also experience glaucomatous changes, including an increas...

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