全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Manuel Román , Gema Gordo ...
来源:[J].International Journal of Antimicrobial Agents(IF 4.415), 2019, Vol.54 (4), pp.463-470Elsevier
摘要:ABSTRACT(#br)Individualisation of the therapeutic strategy for the oral antifungal agent voriconazole (VCZ) is extremely important for treatment optimisation. To date, regulatory agencies include CYP2C19 as the only major pharmacogenetic (PGx) biomarker in their dosing guide...
作者:Manuel Román , Mónica Aguilar ...
来源:[J].Advances in Therapy(IF 2.125), 2019, Vol.36 (10), pp.2744-2755Springer
摘要:Abstract(#br) Introduction(#br)Exogenous progesterone is prescribed for a variety of conditions with endogenous progesterone deficiency, e.g. menstrual alterations, primary or secondary infertility or premenopause. To the best of our knowledge, no pharmacogenetic studies have bee...
作者:Manuel Román , Teresa Cabaleiro ...
来源:[J].Clinical Therapeutics(IF 2.23), 2012, Vol.34 (4), pp.878-884Elsevier
摘要:Abstract(#br)Background(#br)Thiopurine methyltransferase (TPMT) catalyzes the methylation of thiopurine drugs such as azathioprine and 6-mercaptopurine. Several mutations in the TPMT gene correlate with low enzyme activity and adverse effects such as myelotoxicity. Hence, genotyp...
作者:Manuel Román , Dolores Ochoa
来源:[J].Journal of Pharmaceutical and Biomedical Analysis(IF 2.947), 2018, Vol.151, pp.116-125Elsevier
摘要:Abstract(#br)A simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for simultaneous quantification of aripiprazole and its active metabolite, dehydro-aripiprazole, in human plasma. Stable isotopically labeled aripiprazole,...
作者:Manuel Román , Jesús Novalbos ...
来源:[J].Human Psychopharmacology: Clinical and Experimental(IF 2.097), 2014, Vol.29 (5), pp.459-469Wiley
摘要:Objective(#br)To identify genetic markers capable of predicting the pharmacokinetics, pharmacodynamics, and adverse effects of risperidone.(#br)Methods(#br)Genotyping was performed in 70 healthy volunteers receiving a single 1 mg oral dose of risperidone. Risperidone and hyd...

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