全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Manjusha M. Kulkarni , Annette N. Ratcliff ...
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purine binding pockets, purinome proteins are highly druggable, and many exis...
作者:Manjusha M. Kulkarni , Anna Karafova ...
来源:[J].Parasitology Research(IF 2.852), 2014, Vol.113 (5), pp.1971-1976Springer
摘要:Abstract(#br)Antimicrobial peptides are increasingly being explored as alternative agents for therapy against the parasitic protozoan Leishmania . Previously, we reported that the synthetic magainin analog, pexiganan, induced apoptosis of surface protease-deficient Leishmania. He...
作者:Manjusha M. Kulkarni , Niveditha Reddy ...
来源:[J].Parasitology Research(IF 2.852), 2013, Vol.112 (5), pp.2095-2099Springer
摘要:Abstract(#br)The digenetic protozoan Leishmania is dependent on ergosterol synthesis for growth and viability. We compared the in vitro activity of ergosterol synthesis inhibitor voriconazole with fluconazole and ketoconazole against cutaneous and visceral Leishmania species. We ...
作者:Bradford S. McGwire , Manjusha M. Kulkarni
来源:[J].Experimental Parasitology(IF 2.154), 2010, Vol.126 (3), pp.397-405Elsevier
摘要:Abstract(#br)Antimicrobial peptides (AMPs) are multifunctional components of the innate systems of both insect and mammalian hosts of the pathogenic trypanosomatids Leishmania and Trypanosoma species. Structurally diverse AMPs from a wide range of organisms have in vitro activity...
作者:Manjusha M. Kulkarni , Sanjay Varikuti ...
来源:[J].Immunology(IF 3.705), 2015, Vol.145 (2), pp.225-231Wiley
摘要:Summary(#br)The control of Trypanosoma cruzi infection is related to interferon‐ γ ( IFN ‐ γ ) activation leading to intracellular clearance of parasites. The transcription factor signal transducer and activator of transcription 1 ( STAT ‐1) is a key mediator of IF...
作者:Manjusha M. Kulkarni , Annette N. Ratcliff ...
来源:[J].Cell Chemical Biology, 2016, Vol.23 (6), pp.678-688Elsevier
摘要:Summary(#br)Many tumors are dependent on de novo fatty acid synthesis to maintain cell growth. Fatty acid synthase (FASN) catalyzes the final synthetic step of this pathway, and its upregulation is correlated with tumor aggressiveness. The consequences and adaptive responses of a...

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