全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Mahmoud Alhosin , Abdulkhaleg Ibrahim ...
来源:[J].Journal of Experimental & Clinical Cancer Research(IF 3.066), 2017, Vol.36 (1)Springer
摘要:The nuclear epigenetic integrator UHRF1 is known to play a key role with DNMT1 in maintaining the DNA methylation patterns during cell division. Among UHRF1 partners, TIP60 takes part in epigenetic regulations through its acetyltransferase activity. Both proteins are involved in ...
作者:Mahmoud Alhosin , Ziad Omran ...
来源:[J].Journal of Experimental & Clinical Cancer Research(IF 3.066), 2016, Vol.35 (1)Springer
摘要:Abstract(#br)Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and histone changes is a main hallmark of cancer. U biquitin-like with P H D and R ING F inger domains 1 (UHRF1) is a potent oncogene overexpressed in various solid and haematological tumor...
作者:Mahmoud Alhosin , Eric Anselm ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (3)DOAJ
摘要:The vascular protective effect of grape-derived polyphenols has been attributable, in part, to their direct action on blood vessels by stimulating the endothelial formation of nitric oxide (NO). The aim of the present study was to determine whether Concord grape juice (CGJ), whic...
作者:Mahmoud Alhosin , Tanveer Sharif ...
来源:[J].Journal of Experimental & Clinical Cancer Research(IF 3.066), 2011, Vol.30 (1)Springer
摘要:Abstract(#br)Over-expressed in numerous cancers, Ubiquitin-like containing PHD Ring Finger 1 (UHRF1, also known as ICBP90 or Np95 ) is characterized by a SRA domain (Set and Ring Associated) which is found only in the UHRF family. UHRF1 constitutes a complex with histone deacetyl...
作者:Mahmoud Alhosin , Elhassan Yala ...
来源:[J].Journal of Cystic Fibrosis(IF 2.873), 2014, Vol.13 (2), pp.219-226Elsevier
摘要:Abstract(#br)Background(#br)Diabetes in cystic fibrosis (CF) is a result of exocrine pancreas alteration followed by endocrine dysfunction at a later stage. Microparticles (MPs) are plasma membrane fragments shed from stimulated or damaged cells that act as cellular effector...
作者:... Philippe Chabert , Mahmoud Alhosin , Valérie B. Schini-Kerth
来源:[J].Journal of Functional Foods(IF 2.632), 2015, Vol.17, pp.847-856Elsevier
摘要:Abstract(#br)Blackcurrant, a rich source of anthocyanins, has been reported to exhibit an antiproliferative effect on several types of solid tumour cancer cells, but its active molecules and the precise mechanism of their action remain unclear. The aim of the present study was to...
作者:Mahmoud Alhosin , Abdulkhaleg Ibrahim ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2012Elsevier
摘要:Abstract(#br)Ubiquitin-like containing PHD and Ring Finger 1 (UHRF1) contributes to silencing of tumor suppressor genes by recruiting DNA methyltransferase 1 (DNMT1) to their hemi-methylated promoters. Conversely, demethylation of these promoters has been ascribed to the natural ...
作者:Mahmoud Alhosin , Abdulkhaleg Ibrahim ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2013, Vol.430 (1), pp.208-212Elsevier
摘要:Abstract(#br)Ubiquitin-like containing PHD and Ring finger 1 (UHRF1) contributes to silencing of tumor suppressor genes by recruiting DNA methyltransferase 1 (DNMT1) to their hemi-methylated promoters. Conversely, demethylation of these promoters has been ascribed to the natural ...
作者:Mahmoud Alhosin , Abdulkhaleg Ibrahim ...
来源:[J].Investigational New Drugs(IF 3.498), 2012, Vol.30 (5), pp.1813-1819Springer
摘要:Summary(#br)The microtubule-targeting agents derived from natural products, such as vinca- alkaloids and taxanes are an important family of efficient anti-cancer drugs with therapeutic benefits in both haematological and solid tumors. These drugs interfere with the assembly ...
作者:Mahmoud Alhosin , Abdurazzag Abusnina ...
来源:[J].Biochemical Pharmacology(IF 4.576), 2009, Vol.79 (9), pp.1251-1260Elsevier
摘要:Abstract(#br)The salvage anti-tumoral pathway which implicates the p53-related p73 gene is not yet fully characterized. We therefore attempted to identify the up- and down-stream events involved in the activation of the p73-dependent pro-apoptotic pathway, by focusing on the...

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