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作者:M W Laschke , M S Seifert ...
来源:[J].Eur Cell Mater(IF 4.558), 2019, Vol.38, pp.188-200
摘要:High glucose concentrations have been shown to activate endothelial cells and promote angiogenesis. In the present study, it was investigated whether high glucose concentrations could improve the vascularisation capacity of adipose-tissue-derived microvascular fragments (ad-...
作者:M W Laschke , S Dold ...
来源:[J].British Journal of Pharmacology(IF 5.067), 2008, Vol.153 (1), pp.148-156
摘要:Background:(#br)Although it is well known that extrahepatic cholestasis induces liver damage, the mechanisms are still not completely understood. The aim of the present study was to evaluate the role of platelets and P‐selectin in cholestasis‐induced liver injury.(#br)Experi...
作者:... F S Frueh , M D Menger , M W Laschke
来源:[J].Eur Cell Mater(IF 4.558), 2017, Vol.33, pp.268-278
摘要:Adipose tissue-derived microvascular fragments (ad-MVF) represent promising vascularisation units for bioengineered Integra® matrix wound dressing (MWD). However, due to the sheet-like structure with small pore sizes, the seeding of this matrix with ad-MVF is mainly limited ...
作者:... R M Nickels , M D Menger , M W Laschke
来源:[J].Eur Cell Mater(IF 4.558), 2017, Vol.34, pp.55-69
摘要:Adipose tissue-derived microvascular fragments (ad-MVF) represent effective vascularisation units for the seeding of dermal substitutes. However, particularly in case of extensive skin defects, the required amounts of donor fat tissue for the harvesting of ad-MVF may not alw...
作者:... T Später , M D Menger , M W Laschke
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.35, pp.268-280
摘要:The seeding of tissue constructs with adipose tissue-derived microvascular fragments (ad-MVF) is an emerging pre-vascularisation strategy. Ad-MVF rapidly reassemble into new microvascular networks after in vivo implantation. Herein it was analysed whether this process was improve...
作者:... T Pohlemann , M W Laschke , M D Menger
来源:[J].Eur Cell Mater(IF 4.558), 2017, Vol.33, pp.1-12
摘要:Atrophic non-unions are a major clinical problem. Mineral coated microparticles (MCM) are electrolyte-coated hydroxyapatite particles that have been shown in vitro to bind growth factors electrostatically and enable a tuneable sustained release. Herein, we studied whether MC...
作者:M W Laschke , C Scheuer ...
来源:[J].British Journal of Pharmacology(IF 5.067), 2008, Vol.154 (5), pp.1055-1062
摘要:Background and purpose:(#br)The immunosuppressive drug rapamycin (RAPA) prevents rejection in organ transplantation by inhibiting interleukin‐2‐stimulated T‐cell division. Rapamycin has also been suggested to possess strong anti‐angiogenic activities linked to a decreas...
作者:M W Laschke , S Kleer ...
来源:[J].Eur Cell Mater(IF 4.558), 2015, Vol.29, pp.190-201
摘要:Adipose tissue-derived microvascular fragments represent promising vascularisation units for implanted tissue constructs. However, their reassembly into functional microvascular networks takes several days, during which the cells inside the implants are exposed to hypoxia. In the...
作者:M W Laschke , M D Menger
来源:[J].Eur Cell Mater(IF 4.558), 2016, Vol.32, pp.202-215
摘要:The dorsal skinfold chamber is a rodent model for non-invasive microcirculatory analyses of striated muscle and skin tissue throughout an observation period of 2-3 weeks. In combination with intravital fluorescence microscopy, this model allows the quantitative assessment of dyna...
作者:... D Eglin , M D Menger , M W Laschke
来源:[J].Eur Cell Mater(IF 4.558), 2016, Vol.32, pp.74-86
摘要:The seeding of scaffolds with adipose tissue-derived microvascular fragments represents a promising strategy to establish a sufficient blood supply in tissue constructs. Herein, we analysed whether a single application of macrophage-activating lipopeptide-2 (MALP-2) at the implan...

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